A phase II study of the survivin suppressant YM155 in patients with refractory diffuse large B-cell lymphoma

Bruce D. Cheson, Nancy L. Bartlett, Julie M. Vose, Andres Lopez-Hernandez, Amanda L. Seiz, Anne T. Keating, Setareh Shamsili

Research output: Contribution to journalArticlepeer-review

83 Scopus citations

Abstract

BACKGROUND: Few effective therapeutic options exist for patients with refractory diffuse large B-cell lymphoma (DLBCL). YM155 is a survivin suppressant with activity against DLBCL in a phase I trial. This phase II study was conducted to better characterize the toxicity and efficacy of this small molecule in patients with refractory DLBCL. METHODS: Forty-one patients with a median age of 66 years and 3 prior regimens were enrolled and treated with a YM155 dose of 5 mg/m2/d by continuous infusion for 168 hours every 21 days for up to 15 cycles of treatment. The median number of completed cycles was 3. RESULTS: One patient had a complete remission (CR) (2.4%) with an additional 2 patients (5.9%) responding, with a median progression-free survival of 58 days. CONCLUSIONS: YM155 was well tolerated with major toxicities including anemia and fatigue. Whereas YM155 had limited single-agent activity, preclinical data suggest its role in combination with other agents, including rituximab, and a study of that combination in ongoing.

Original languageEnglish (US)
Pages (from-to)3128-3134
Number of pages7
JournalCancer
Volume118
Issue number12
DOIs
StatePublished - Jun 15 2012

Keywords

  • Biological therapy
  • Clinical trial
  • Diffuse large B-cell
  • Non-Hodgkin's lymphoma
  • Survivin

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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