A pleiotropic response associated with resistance of breast cancer cells to antineoplastic drugs and hormonal agents

Philip P. Vickers; Robert B. Dixon; Kenneth H. Cowan

doi:10.1016/0165-6147(88)90135-6

A pleiotropic response associated with resistance of breast cancer cells to antineoplastic drugs and hormonal agents

Philip P. Vickers, Robert B. Dixon, Kenneth H. Cowan

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Abstract

A multidrug-resistant variant of the human breast cancer cell line MCF-7 exhibits multiple biochemical changes including reduced estrogen receptor and increased EGF receptor levels, overexpression of the putative drug efflux pump and cross-resistance to carcinogens, estrogens and antiestrogens. Philip Vickers and colleagues consider the usefulness of this model to the study of clinical transition of breast cancer to a hormonally unresponsive, highly malignant state.

Original language	English (US)
Pages (from-to)	443-445
Number of pages	3
Journal	Trends in Pharmacological Sciences
Volume	9
Issue number	12
DOIs	https://doi.org/10.1016/0165-6147(88)90135-6
State	Published - Dec 1988
Externally published	Yes

ASJC Scopus subject areas

Toxicology
Pharmacology

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abstract = "A multidrug-resistant variant of the human breast cancer cell line MCF-7 exhibits multiple biochemical changes including reduced estrogen receptor and increased EGF receptor levels, overexpression of the putative drug efflux pump and cross-resistance to carcinogens, estrogens and antiestrogens. Philip Vickers and colleagues consider the usefulness of this model to the study of clinical transition of breast cancer to a hormonally unresponsive, highly malignant state.",

author = "Vickers, {Philip P.} and Dixon, {Robert B.} and Cowan, {Kenneth H.}",

year = "1988",

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AU - Vickers, Philip P.

AU - Dixon, Robert B.

AU - Cowan, Kenneth H.

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N2 - A multidrug-resistant variant of the human breast cancer cell line MCF-7 exhibits multiple biochemical changes including reduced estrogen receptor and increased EGF receptor levels, overexpression of the putative drug efflux pump and cross-resistance to carcinogens, estrogens and antiestrogens. Philip Vickers and colleagues consider the usefulness of this model to the study of clinical transition of breast cancer to a hormonally unresponsive, highly malignant state.

AB - A multidrug-resistant variant of the human breast cancer cell line MCF-7 exhibits multiple biochemical changes including reduced estrogen receptor and increased EGF receptor levels, overexpression of the putative drug efflux pump and cross-resistance to carcinogens, estrogens and antiestrogens. Philip Vickers and colleagues consider the usefulness of this model to the study of clinical transition of breast cancer to a hormonally unresponsive, highly malignant state.

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DO - 10.1016/0165-6147(88)90135-6

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JO - Trends in Pharmacological Sciences

JF - Trends in Pharmacological Sciences

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ER -

A pleiotropic response associated with resistance of breast cancer cells to antineoplastic drugs and hormonal agents

Abstract

ASJC Scopus subject areas

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