A pleiotropic response associated with resistance of breast cancer cells to antineoplastic drugs and hormonal agents

Philip P. Vickers, Robert B. Dixon, Kenneth H. Cowan

Research output: Contribution to journalReview article

6 Scopus citations

Abstract

A multidrug-resistant variant of the human breast cancer cell line MCF-7 exhibits multiple biochemical changes including reduced estrogen receptor and increased EGF receptor levels, overexpression of the putative drug efflux pump and cross-resistance to carcinogens, estrogens and antiestrogens. Philip Vickers and colleagues consider the usefulness of this model to the study of clinical transition of breast cancer to a hormonally unresponsive, highly malignant state.

Original languageEnglish (US)
Pages (from-to)443-445
Number of pages3
JournalTrends in Pharmacological Sciences
Volume9
Issue number12
DOIs
StatePublished - Dec 1988

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

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