A possible etiology of the infertile 46XX male subject

M. G. Butler, M. P. Walzak, W. G. Sanger, C. T. Todd

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


We report on an infertile male patient with the predominant 46XX female karyotype. A testicular biopsy revealed widely separated testicular tubules, absence of sperm formation and large numbers of Leydig cells. Chromosome studies, including measurement of the X chromosomes, showed a significant difference between the lengths of the short arm of the 2 X chromosomes. This information lends support for an X-Y chromosome interchange as the etiology of this syndrome. The clinical features of this rare syndrome and other theories of etiology of the XX male subjects are discussed.

Original languageEnglish (US)
Pages (from-to)154-156
Number of pages3
JournalJournal of Urology
Issue number1
StatePublished - 1983
Externally publishedYes

ASJC Scopus subject areas

  • Urology


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