A possible etiology of the infertile 46XX male subject

M. G. Butler; M. P. Walzak; W. G. Sanger; C. T. Todd

doi:10.1016/S0022-5347(17)51010-1

A possible etiology of the infertile 46XX male subject

M. G. Butler, M. P. Walzak, W. G. Sanger, C. T. Todd

Research output: Contribution to journal › Article › peer-review

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Abstract

We report on an infertile male patient with the predominant 46XX female karyotype. A testicular biopsy revealed widely separated testicular tubules, absence of sperm formation and large numbers of Leydig cells. Chromosome studies, including measurement of the X chromosomes, showed a significant difference between the lengths of the short arm of the 2 X chromosomes. This information lends support for an X-Y chromosome interchange as the etiology of this syndrome. The clinical features of this rare syndrome and other theories of etiology of the XX male subjects are discussed.

Original language	English (US)
Pages (from-to)	154-156
Number of pages	3
Journal	Journal of Urology
Volume	130
Issue number	1
DOIs	https://doi.org/10.1016/S0022-5347(17)51010-1
State	Published - 1983
Externally published	Yes

ASJC Scopus subject areas

Urology

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10.1016/S0022-5347(17)51010-1

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title = "A possible etiology of the infertile 46XX male subject",

abstract = "We report on an infertile male patient with the predominant 46XX female karyotype. A testicular biopsy revealed widely separated testicular tubules, absence of sperm formation and large numbers of Leydig cells. Chromosome studies, including measurement of the X chromosomes, showed a significant difference between the lengths of the short arm of the 2 X chromosomes. This information lends support for an X-Y chromosome interchange as the etiology of this syndrome. The clinical features of this rare syndrome and other theories of etiology of the XX male subjects are discussed.",

author = "Butler, {M. G.} and Walzak, {M. P.} and Sanger, {W. G.} and Todd, {C. T.}",

year = "1983",

doi = "10.1016/S0022-5347(17)51010-1",

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T1 - A possible etiology of the infertile 46XX male subject

AU - Butler, M. G.

AU - Walzak, M. P.

AU - Sanger, W. G.

AU - Todd, C. T.

PY - 1983

Y1 - 1983

N2 - We report on an infertile male patient with the predominant 46XX female karyotype. A testicular biopsy revealed widely separated testicular tubules, absence of sperm formation and large numbers of Leydig cells. Chromosome studies, including measurement of the X chromosomes, showed a significant difference between the lengths of the short arm of the 2 X chromosomes. This information lends support for an X-Y chromosome interchange as the etiology of this syndrome. The clinical features of this rare syndrome and other theories of etiology of the XX male subjects are discussed.

AB - We report on an infertile male patient with the predominant 46XX female karyotype. A testicular biopsy revealed widely separated testicular tubules, absence of sperm formation and large numbers of Leydig cells. Chromosome studies, including measurement of the X chromosomes, showed a significant difference between the lengths of the short arm of the 2 X chromosomes. This information lends support for an X-Y chromosome interchange as the etiology of this syndrome. The clinical features of this rare syndrome and other theories of etiology of the XX male subjects are discussed.

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JO - Journal of Urology

JF - Journal of Urology

IS - 1

ER -

A possible etiology of the infertile 46XX male subject

Abstract

ASJC Scopus subject areas

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