TY - JOUR
T1 - A possible role for catecholamine neurotransmitters in the anticonvulsant activity of chlordiazepoxide
AU - Yutrzenka, G. J.
AU - Davis, J. S.
AU - Parmar, S. S.
PY - 1980
Y1 - 1980
N2 - The role of catecholamines, in the central nervous system, as mediators of the anticonvulsant activity of chlordiazepoxide, was investigated. Chlordiazepoxide in doses of 2.5 mg/kg and 5.0 mg/kg provided dose-dependent protection from pentylenetetrazol-induced seizures in male albino mice. Treatment of mice with either α-methyl-p-tyrosine, phenoxybenzamine, propranolol or L-dopa, prior to the administration of chlordiazepoxide potentiated the anticonvulsant activity of chlordiazepoxide. This was reflected by an increase in the degree of protection from convulsions, a decrease in ED50 value, and an increased time to onset of seizures in pretreated mice. Administration of disulfiram prior to the administration of chlordiazepoxide was shown to provide no significant increase in the anticonvulsant activity of chlordiazepoxide. These results have provided evidence for the role of catecholamine neurotransmitters as possible mediators of the anticonvulsant activity of chlordiazepoxide.
AB - The role of catecholamines, in the central nervous system, as mediators of the anticonvulsant activity of chlordiazepoxide, was investigated. Chlordiazepoxide in doses of 2.5 mg/kg and 5.0 mg/kg provided dose-dependent protection from pentylenetetrazol-induced seizures in male albino mice. Treatment of mice with either α-methyl-p-tyrosine, phenoxybenzamine, propranolol or L-dopa, prior to the administration of chlordiazepoxide potentiated the anticonvulsant activity of chlordiazepoxide. This was reflected by an increase in the degree of protection from convulsions, a decrease in ED50 value, and an increased time to onset of seizures in pretreated mice. Administration of disulfiram prior to the administration of chlordiazepoxide was shown to provide no significant increase in the anticonvulsant activity of chlordiazepoxide. These results have provided evidence for the role of catecholamine neurotransmitters as possible mediators of the anticonvulsant activity of chlordiazepoxide.
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M3 - Article
AN - SCOPUS:0019255541
VL - 5
SP - 407
EP - 418
JO - Research Communications in Psychology, Psychiatry and Behavior
JF - Research Communications in Psychology, Psychiatry and Behavior
SN - 0362-2428
IS - 4
ER -