TY - JOUR
T1 - A potent modifier of liver cancer risk on distal mouse chromosome 1
T2 - Linkage analysis and characterization of congenic lines
AU - Bilger, Andrea
AU - Bennett, L. Michelle
AU - Carabeo, Reynaldo A.
AU - Chiaverotti, Teresa A.
AU - Dvorak, Cecily
AU - Liss, Kristin M.
AU - Schadewald, Susan A.
AU - Pitot, Henry C.
AU - Drinkwater, Norman R.
PY - 2004/6
Y1 - 2004/6
N2 - The C3H/HeJ (C3H) and CBA/J (CBA) mouse strains are classical mouse models of cancer susceptibility, exhibiting high risks for both spontaneous and chemically induced liver cancer. By analysis of backcrosses and intercrosses between C3H or CBA and resistant B6 mice, we have mapped a potent modifier of hepatocellular carcinoma development to distal chromosome 1, linked to the marker D1Mit33 with combined LODW scores of ∼5.9 (C3H) and 6.5 (CBA). We previously identified this region as one of two that modify susceptibility in the more distantly related C57BR/cdJ (BR) strain. Congenic B6.C3H(D1Mit5-D1Mit17) and B6.BR(D1Mit5-D1Mit17) mice developed significantly more liver tumors than B6 mice did (6- to 13-fold, P < 10-11, in males; 3- to 4-fold, P < 10-3, in females). Thus, distal chromosome 1 carries one or more genes that are sufficient to confer susceptibility to liver cancer.
AB - The C3H/HeJ (C3H) and CBA/J (CBA) mouse strains are classical mouse models of cancer susceptibility, exhibiting high risks for both spontaneous and chemically induced liver cancer. By analysis of backcrosses and intercrosses between C3H or CBA and resistant B6 mice, we have mapped a potent modifier of hepatocellular carcinoma development to distal chromosome 1, linked to the marker D1Mit33 with combined LODW scores of ∼5.9 (C3H) and 6.5 (CBA). We previously identified this region as one of two that modify susceptibility in the more distantly related C57BR/cdJ (BR) strain. Congenic B6.C3H(D1Mit5-D1Mit17) and B6.BR(D1Mit5-D1Mit17) mice developed significantly more liver tumors than B6 mice did (6- to 13-fold, P < 10-11, in males; 3- to 4-fold, P < 10-3, in females). Thus, distal chromosome 1 carries one or more genes that are sufficient to confer susceptibility to liver cancer.
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U2 - 10.1534/genetics.103.024521
DO - 10.1534/genetics.103.024521
M3 - Article
C2 - 15238534
AN - SCOPUS:3142670509
VL - 167
SP - 859
EP - 866
JO - Genetics
JF - Genetics
SN - 0016-6731
IS - 2
ER -