A Practical Format to Organize Cancer Constellations Using Innate Immune System Biomarkers: Implications for Early Diagnosis and Prognostication

Martin Tobi, Harvinder Talwar, Noreen F. Rossi, Warren Lockette, Benita McVicker

Research output: Contribution to journalArticlepeer-review

Abstract

Cancer discovery is directed at the identification of a specific cancer type which allows for specific therapeutic interventions. Background/Objectives: Recently, similar immune checkpoint therapeutics have been applied with success across several cancer types, opening the field for other immune disruptive interventions that have practical applications. Methods: We have discovered an innate immune system (InImS) biomarker that allows for the characterization of allied cancer subtypes and outliers that might aid with diagnosis, treatment, and prognostication. Results: These InImS biomarkers are related to PD-L1 treatment outcomes and can be potentially manipulated by dietary means. Conclusions: The FERAD (ferritin–fecal p87) and absolute neutrophil/lymphocyte (aNLR) ratios are two such InImS biomarkers and we show herein, that they allow for the discovery of diagnosis and prognostication patterns, as demonstrated by this study.

Original languageEnglish (US)
Pages (from-to)726-739
Number of pages14
JournalInternational Journal of Translational Medicine
Volume4
Issue number4
DOIs
StatePublished - Dec 2024

Keywords

  • Adnab-9
  • FERAD ratio
  • PD-L1 treatment outcomes
  • absolute neutrophil/lymphocyte ratio
  • cancer constellations
  • p87

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • Medicine (miscellaneous)
  • Genetics
  • Immunology

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