A predominance of the T cell receptor Vγ2/Vδ2 subset in human Mycobacteria-responsive T cells suggests germline gene encoded recognition

G. Panchamoorthy, J. McLean, R. L. Modlin, C. T. Morita, S. Ishikawa, M. B. Brenner, H. Band

Research output: Contribution to journalArticlepeer-review

107 Scopus citations

Abstract

Little is known about the nature of Ag recognition by the TCR-γδ. The recent observation that γδ T cells preferentially recognize mycobacterial Ag provides a model to examine the molecular basis of γδ-TCR recognition. Here, examination of the Mycobacteria-stimulated peripheral blood T cells with TCR-specific mAb revealed a predominance of T cells bearing Vγ2/Vδ2 gene products. PCR cloning and sequence analysis of the TCR chains demonstrated extensive junctional diversity indicating that the response was polyclonal. The marked in vitro γδ T cell response to Mycobacteria was also detected in newborns before encounters with foreign Ag and exclusively involved the same V-gene usage observed in adults. Together, these results suggest that a major mechanism of γδ T cell reactivity involves recognition mediated by germline-encoded segments of the TCR.

Original languageEnglish (US)
Pages (from-to)3360-3369
Number of pages10
JournalJournal of Immunology
Volume147
Issue number10
StatePublished - 1991

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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