A preliminary investigation of the possible hypoglycaemic activity of asteracanthus longifolia

M. R. Fernando; S. M.D.Nalinie Wickramasinghe; M. Ira Thabrew; E. H. Karunanayaka

doi:10.1016/0378-8741(89)90072-X

A preliminary investigation of the possible hypoglycaemic activity of asteracanthus longifolia

M. R. Fernando, S. M.D.Nalinie Wickramasinghe, M. Ira Thabrew, E. H. Karunanayaka

Obstetrics/Gynecology

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Abstract

Investigations were carried out to confirm or otherwise disprove the view held by many Ayurvedic and other traditional medical practitioners in Sri Lanka, that Asteracanthus longifolia possesses hypoglycaemic properties. The effects of an aqueous extract of the whole plant on fasting blood glucose level and glucose tolerance were investigated using Sprague-Dawley rats. The results indicate that aqueous extracts of A. longifolia can significantly lower the fasting blood glucose level and markedly improve the glucose tolerance of the rats. The hypoglycaemic effect produced by a therapeutic dose (equivalent to 5 g/kg of starting material) was comparable to that produced by a therapeutic dose (15 mg/kg of tolbutamide. The magnitude of the hypoglycaemic effect was found to vary with the dosage administered and the storage time of the prepared extract.

Original language	English (US)
Pages (from-to)	7-14
Number of pages	8
Journal	Journal of Ethnopharmacology
Volume	27
Issue number	1-2
DOIs	https://doi.org/10.1016/0378-8741(89)90072-X
State	Published - Nov 1989

ASJC Scopus subject areas

Pharmacology
Drug Discovery

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title = "A preliminary investigation of the possible hypoglycaemic activity of asteracanthus longifolia",

abstract = "Investigations were carried out to confirm or otherwise disprove the view held by many Ayurvedic and other traditional medical practitioners in Sri Lanka, that Asteracanthus longifolia possesses hypoglycaemic properties. The effects of an aqueous extract of the whole plant on fasting blood glucose level and glucose tolerance were investigated using Sprague-Dawley rats. The results indicate that aqueous extracts of A. longifolia can significantly lower the fasting blood glucose level and markedly improve the glucose tolerance of the rats. The hypoglycaemic effect produced by a therapeutic dose (equivalent to 5 g/kg of starting material) was comparable to that produced by a therapeutic dose (15 mg/kg of tolbutamide. The magnitude of the hypoglycaemic effect was found to vary with the dosage administered and the storage time of the prepared extract.",

author = "Fernando, {M. R.} and Wickramasinghe, {S. M.D.Nalinie} and Thabrew, {M. Ira} and Karunanayaka, {E. H.}",

note = "Funding Information: This work was supported by Grant No. TWAS RG 6%SRI 4 from the Third World Academy of Sciences, Trieste, Italy.",

year = "1989",

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T1 - A preliminary investigation of the possible hypoglycaemic activity of asteracanthus longifolia

AU - Fernando, M. R.

AU - Wickramasinghe, S. M.D.Nalinie

AU - Thabrew, M. Ira

AU - Karunanayaka, E. H.

N1 - Funding Information: This work was supported by Grant No. TWAS RG 6%SRI 4 from the Third World Academy of Sciences, Trieste, Italy.

PY - 1989/11

Y1 - 1989/11

N2 - Investigations were carried out to confirm or otherwise disprove the view held by many Ayurvedic and other traditional medical practitioners in Sri Lanka, that Asteracanthus longifolia possesses hypoglycaemic properties. The effects of an aqueous extract of the whole plant on fasting blood glucose level and glucose tolerance were investigated using Sprague-Dawley rats. The results indicate that aqueous extracts of A. longifolia can significantly lower the fasting blood glucose level and markedly improve the glucose tolerance of the rats. The hypoglycaemic effect produced by a therapeutic dose (equivalent to 5 g/kg of starting material) was comparable to that produced by a therapeutic dose (15 mg/kg of tolbutamide. The magnitude of the hypoglycaemic effect was found to vary with the dosage administered and the storage time of the prepared extract.

AB - Investigations were carried out to confirm or otherwise disprove the view held by many Ayurvedic and other traditional medical practitioners in Sri Lanka, that Asteracanthus longifolia possesses hypoglycaemic properties. The effects of an aqueous extract of the whole plant on fasting blood glucose level and glucose tolerance were investigated using Sprague-Dawley rats. The results indicate that aqueous extracts of A. longifolia can significantly lower the fasting blood glucose level and markedly improve the glucose tolerance of the rats. The hypoglycaemic effect produced by a therapeutic dose (equivalent to 5 g/kg of starting material) was comparable to that produced by a therapeutic dose (15 mg/kg of tolbutamide. The magnitude of the hypoglycaemic effect was found to vary with the dosage administered and the storage time of the prepared extract.

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A preliminary investigation of the possible hypoglycaemic activity of asteracanthus longifolia

Abstract

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