A proline-based phosphine template for Staudinger ligation

Chung Min Park, Wei Niu, Chunrong Liu, Tyler D. Biggs, Jiantao Guo, Ming Xian

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

A proline-based phosphine template enabling a rapid Staudinger ligation of azide-containing substrates under mild conditions is reported. This reaction has a second-order rate constant of 1.12 M-1 s-1. It is expected that the proline-based Staudinger ligation strategy will be a useful method for bioconjugation and proline based peptide coupling.

Original languageEnglish (US)
Pages (from-to)4694-4697
Number of pages4
JournalOrganic Letters
Volume14
Issue number17
DOIs
StatePublished - Sep 7 2012

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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