A quantitative trait locus analysis of natural genetic variation for Drosophila melanogaster oxidative stress survival

Yue Wang; David Pot; Stephen D. Kachman; Sergey V. Nuzhdin; Lawrence G. Harshman

doi:10.1093/jhered/esl009

A quantitative trait locus analysis of natural genetic variation for Drosophila melanogaster oxidative stress survival

Yue Wang, David Pot, Stephen D. Kachman, Sergey V. Nuzhdin, Lawrence G. Harshman

Research output: Contribution to journal › Article › peer-review

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Abstract

Little is known about natural genetic variation for survival under oxidative stress conditions or whether genetic variation for oxidative stress survival is associated with that for life-history traits. We have investigated survival in a high-oxygen environment at 2 adult densities using a set of recombinant inbred lines (RILs) isolated from a natural population of Drosophila melanogaster. Female and male oxidative stress survival was highly correlated. Quantitative trait loci (QTLs) for oxidative stress survival were identified on both autosomes. These QTLs were sometimes sex or density specific but were most often not. QTLs were identified that colocalize to the same region of the genome as longevity in other studies using the same set of RILs. We also determined early-age egg production and found QTLs for this trait, but there was no support for an association between oxidative stress survival and egg production.

Original language	English (US)
Pages (from-to)	355-366
Number of pages	12
Journal	Journal of Heredity
Volume	97
Issue number	4
DOIs	https://doi.org/10.1093/jhered/esl009
State	Published - Jul 2006
Externally published	Yes

ASJC Scopus subject areas

Biotechnology
Molecular Biology
Genetics
Genetics(clinical)

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10.1093/jhered/esl009

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title = "A quantitative trait locus analysis of natural genetic variation for Drosophila melanogaster oxidative stress survival",

abstract = "Little is known about natural genetic variation for survival under oxidative stress conditions or whether genetic variation for oxidative stress survival is associated with that for life-history traits. We have investigated survival in a high-oxygen environment at 2 adult densities using a set of recombinant inbred lines (RILs) isolated from a natural population of Drosophila melanogaster. Female and male oxidative stress survival was highly correlated. Quantitative trait loci (QTLs) for oxidative stress survival were identified on both autosomes. These QTLs were sometimes sex or density specific but were most often not. QTLs were identified that colocalize to the same region of the genome as longevity in other studies using the same set of RILs. We also determined early-age egg production and found QTLs for this trait, but there was no support for an association between oxidative stress survival and egg production.",

author = "Yue Wang and David Pot and Kachman, {Stephen D.} and Nuzhdin, {Sergey V.} and Harshman, {Lawrence G.}",

note = "Funding Information: The research reported in the present study was supported by a grant to L.G.H. and S.V.N. from the Army Research Office (DAAD 19-03-1-0152).",

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AU - Pot, David

AU - Kachman, Stephen D.

AU - Nuzhdin, Sergey V.

AU - Harshman, Lawrence G.

N1 - Funding Information: The research reported in the present study was supported by a grant to L.G.H. and S.V.N. from the Army Research Office (DAAD 19-03-1-0152).

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N2 - Little is known about natural genetic variation for survival under oxidative stress conditions or whether genetic variation for oxidative stress survival is associated with that for life-history traits. We have investigated survival in a high-oxygen environment at 2 adult densities using a set of recombinant inbred lines (RILs) isolated from a natural population of Drosophila melanogaster. Female and male oxidative stress survival was highly correlated. Quantitative trait loci (QTLs) for oxidative stress survival were identified on both autosomes. These QTLs were sometimes sex or density specific but were most often not. QTLs were identified that colocalize to the same region of the genome as longevity in other studies using the same set of RILs. We also determined early-age egg production and found QTLs for this trait, but there was no support for an association between oxidative stress survival and egg production.

AB - Little is known about natural genetic variation for survival under oxidative stress conditions or whether genetic variation for oxidative stress survival is associated with that for life-history traits. We have investigated survival in a high-oxygen environment at 2 adult densities using a set of recombinant inbred lines (RILs) isolated from a natural population of Drosophila melanogaster. Female and male oxidative stress survival was highly correlated. Quantitative trait loci (QTLs) for oxidative stress survival were identified on both autosomes. These QTLs were sometimes sex or density specific but were most often not. QTLs were identified that colocalize to the same region of the genome as longevity in other studies using the same set of RILs. We also determined early-age egg production and found QTLs for this trait, but there was no support for an association between oxidative stress survival and egg production.

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A quantitative trait locus analysis of natural genetic variation for Drosophila melanogaster oxidative stress survival

Abstract

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