A red Cy3-based biarsenical fluorescent probe targeted to a complementary binding peptide

Haishi Cao, Yijia Xiong, Ting Wang, Baowei Chen, Thomas C. Squier, M. Uljana Mayer

Research output: Contribution to journalArticlepeer-review

79 Scopus citations

Abstract

We have synthesized a red biarsenical fluorescent probe, AsCy3, with good photostability, low pH sensitivity, high absorbance, and good quantum yield. It is directed specifically to a small tetracysteine peptide binding motif, Cy3TAG (CysCysLysAlaGluAlaAlaCysCys), in the presence of other tetracysteine tags. This new probe provides a FRET partner to biarsenical dye FlAsH, making this discovery an important step toward a whole toolkit of colored probes directed to different small peptide motifs.

Original languageEnglish (US)
Pages (from-to)8672-8673
Number of pages2
JournalJournal of the American Chemical Society
Volume129
Issue number28
DOIs
StatePublished - Jul 18 2007

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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