A review of animal models used to evaluate potential allergenicity of genetically modified organisms (GMOs)

Nathan Marsteller, Katrine L. Bøgh, Richard E. Goodman, Michelle M. Epstein

Research output: Contribution to journalReview article

2 Scopus citations

Abstract

Food safety regulators request prediction of allergenicity for newly expressed proteins in genetically modified (GM) crops and in novel foods. Some have suggested using animal models to assess potential allergenicity. A variety of animal models have been used in research to evaluate sensitisation or elicitation of allergic responses. However, protocols for sensitisation and challenge, animal species and strains, diets and other environmental factors differ widely. We present a comprehensive review of published, peer-reviewed experimental animal models used for the evaluation of allergenicity of genetically modified organisms (GMOs).

Original languageEnglish (US)
Pages (from-to)81-88
Number of pages8
JournalDrug Discovery Today: Disease Models
Volume17-18
DOIs
StatePublished - Feb 4 2015

    Fingerprint

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

Cite this