A review of hereditary malignant melanoma including biomarkers in familial atypical multiple mole melanoma syndrome

Henry T. Lynch, Ramon M. Fusaro, B. Shannon Danes, William J. Kimberling, Jane F. Lynch

    Research output: Contribution to journalReview articlepeer-review

    41 Scopus citations

    Abstract

    This review provides a comprehensive coverage of hereditary maliganant melanoma with emphasis upon its heterogeneity as well as newly developed biomarker investigations. The recently described familial atypical multiple mole melanoma (FAMMM) syndrome is featured. Particular attention has been given to findings of increased hyperdiploidy observed as an in vitro phenomenon in cultured skin fibroblasts from high-risk and FAMMM-affected subjects. The FAMMM genotype is complex in that it predisposes a patient not only to melanoma (cutaneous and intraocular malignant melanoma) but also to other histologic varieties of cancer, including cancer of the lung, pancreas, and breast. Attention is given to cancer surveillance and management programs for patients at increased risk for the several forms of hereditary malignant melanoma. This approach capitalizes advantageously upon employment of a knowledge of genetics and hereditary cancer syndrome identification, with particular attention to tumor associations.

    Original languageEnglish (US)
    Pages (from-to)325-358
    Number of pages34
    JournalCancer genetics and cytogenetics
    Volume8
    Issue number4
    DOIs
    StatePublished - Apr 1983

    ASJC Scopus subject areas

    • Molecular Biology
    • Genetics
    • Cancer Research

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