A Review of Human Ocular RNA Virus Infections Excluding Coronavirus, Human T-Cell Lymphotropic Virus, and Arboviruses

Derrick P. Smit, Dony K. Mathew, Moncef Khairallah, Steven Yeh, Emmett T. Cunningham

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

We provide an updated review of pre-selected RNA viruses causing ocular inflammation in humans. RNA viruses such as coronaviruses and arboviruses are reviewed elsewhere. A Google Scholar search was conducted to identify recent publications on ocular inflammation caused by the RNA viruses specified here. Human RNA viruses target a wide range of ocular tissues from the anterior to the posterior. Influenza, measles and mumps cause anterior segment manifestations including conjunctivitis and keratitis, while retinitis and optic neuritis may be seen posteriorly. Newcastle disease and RSV cause conjunctivitis, whereas HIV causes characteristic anterior uveitis. Cataracts, microphthalmos, and iris abnormalities are common in congenital Rubella, while Rubella virus is associated with Fuchs uveitis syndrome. Newer technologies make it possible to detect more than one pathogen if present simultaneously. RNA viruses may produce significant ocular morbidity, and care should be taken to investigate ocular symptoms during disease outbreaks.

Original languageEnglish (US)
Pages (from-to)1454-1460
Number of pages7
JournalOcular Immunology and Inflammation
Volume31
Issue number7
DOIs
StatePublished - 2023

Keywords

  • HIV
  • RNA viruses
  • ocular inflammation
  • rubella
  • uveitis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Ophthalmology

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