A review of renal tubular acidosis

Manju Gauri Kunchur, Teri Jo Mauch, Max Parkanzky, Louisa J. Rahilly

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Objective: To review the current scientific literature on renal tubular acidosis (RTA) in people and small animals, focusing on diseases in veterinary medicine that result in secondary RTA. Data Sources: Scientific reviews and original research publications on people and small animals focusing on RTA. Summary: RTA is characterized by defective renal acid–base regulation that results in normal anion gap hyperchloremic metabolic acidosis. Renal acid–base regulation includes the reabsorption and regeneration of bicarbonate in the renal proximal tubule and collecting ducts and the process of ammoniagenesis. RTA occurs as a primary genetic disorder or secondary to disease conditions. Based on pathophysiology, RTA is classified as distal or type 1 RTA, proximal or type 2 RTA, type 3 RTA or carbonic anhydrase II mutation, and type 4 or hyperkalemic RTA. Fanconi syndrome comprises proximal RTA with additional defects in proximal tubular function. Extensive research elucidating the genetic basis of RTA in people exists. RTA is a genetic disorder in the Basenji breed of dogs, where the mutation is known. Secondary RTA in human and veterinary medicine is the sequela of diseases that include immune-mediated, toxic, and infectious causes. Diagnosis and characterization of RTA include the measurement of urine pH and the evaluation of renal handling of substances that should affect acid or bicarbonate excretion. Conclusions: Commonality exists between human and veterinary medicine among the types of RTA. Many genetic defects causing primary RTA are identified in people, but those in companion animals other than in the Basenji are unknown. Critically ill veterinary patients are often admitted to the ICU for diseases associated with secondary RTA, or they may develop RTA while hospitalized. Recognition and treatment of RTA may reverse tubular dysfunction and promote recovery by correcting metabolic acidosis.

Original languageEnglish (US)
Pages (from-to)325-355
Number of pages31
JournalJournal of Veterinary Emergency and Critical Care
Volume34
Issue number4
DOIs
StatePublished - Jul 1 2024

Keywords

  • acidosis
  • canine
  • renal diseases

ASJC Scopus subject areas

  • General Veterinary

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