A robust microfluidic platform for fabrication of meter-long hydrogel microfibers

Mohsen Akbari, Ludovic Serex, Emal Lesha, Ali Tamayol, Su Ryon Shin, Yu Shrike Zhang, Farhang Tarlan, Koji Futamura, Ali Khademhosseini

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Hydrogel fibers have drawn a great deal of attention during the past few years for a wide range of applications, spanning from tissue engineering to biosensing. Here, we present a double-coaxial flow microfluidic device to assemble fiber-shaped, meter-long fibers consisting of a hydrogel core and an alginate shell. Various hydrogel fibers from collagen type I, GelMA, NiPAM, and agarose have been fabricated with this approach. These fibers were mechanically characterized exhibiting Yong's moduli between ∼10 to ∼200 kPa, making them mechanically suitable for tissue engineering applications. Moreover, we encapsulated human mesenchymal stem cells (MSCs) in collagen fibers and observed proliferation and spreading after 7 days of culture indicating the biocompatibility of the process. The fiber-shaped structures we fabricated can be potentially used for creating three dimensional tissue constructs, wound patches, and flexible biosensors.

Original languageEnglish (US)
Title of host publication18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
PublisherChemical and Biological Microsystems Society
Pages2506-2507
Number of pages2
ISBN (Electronic)9780979806476
StatePublished - 2014
Event18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 - San Antonio, United States
Duration: Oct 26 2014Oct 30 2014

Publication series

Name18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014

Other

Other18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
CountryUnited States
CitySan Antonio
Period10/26/1410/30/14

Keywords

  • Cell-laden fibers
  • Hydrogel fibers
  • Microfluidics
  • Tissue engineering

ASJC Scopus subject areas

  • Control and Systems Engineering

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