A role for the NLRP3 inflammasome in metabolic diseases - Did Warburg miss inflammation?

Haitao Wen, Jenny P.Y. Ting, Luke A.J. O'Neill

Research output: Contribution to journalReview article

287 Scopus citations

Abstract

The inflammasome is a protein complex that comprises an intracellular sensor (typically a Nod-like receptor), the precursor procaspase-1 and the adaptor ASC. Inflammasome activation leads to the maturation of caspase-1 and the processing of its substrates, interleukin 1β (IL-1β) and IL-18. Although initially the inflammasome was described as a complex that affects infection and inflammation, subsequent evidence has suggested that inflammasome activation influences many metabolic disorders, including atherosclerosis, type 2 diabetes, gout and obesity. Another feature of inflammation in general and the inflammasome specifically is that the activation process has a profound effect on aerobic glycolysis (the 'Warburg effect'). Here we explore how the Warburg effect might be linked to inflammation and inflammasome activation.

Original languageEnglish (US)
Pages (from-to)352-357
Number of pages6
JournalNature Immunology
Volume13
Issue number4
DOIs
StatePublished - Apr 2012

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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