A sequential cell kinetic study of meningioma cells in primary explant culture using bromodeoxyuridine

Kusum Kharbanda, Asis K. Karak, Chitra Sarkar, Amit K. Dinda, Meera Mathur, S. Roy

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

The present study was undertaken to evaluate the sequential BrdU-LI at weekly intervals upto four weeks in 18 primary explant cultures of meningiomas. This revealed three distinct patterns of growth which could be arbitrarily defined as 'degenerating' (group I), 'proliferating' (group II) and 'adaptive' (group III) types. Interestingly two cases of malignant and two of recurrent meningiomas fell into the 'degenerating' group I pattern. The possible explanations for the observed relatively higher in vitro LI values compared to lower in vivo values as reported in the literature and the theoretical implications of the three distinct patterns of sequential LI values are discussed.

Original languageEnglish (US)
Pages (from-to)117-123
Number of pages7
JournalJournal of Neuro-Oncology
Volume16
Issue number2
DOIs
StatePublished - Jun 1993

Keywords

  • bromodeoxyuridine
  • histological types
  • malignant
  • meningioma
  • primary cultures
  • recurrent
  • sequential labeling index

ASJC Scopus subject areas

  • Oncology
  • Neurology
  • Clinical Neurology
  • Cancer Research

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