A sequential cell kinetic study of meningioma cells in primary explant culture using bromodeoxyuridine

Kusum Kharbanda; Asis K. Karak; Chitra Sarkar; Amit K. Dinda; Meera Mathur; S. Roy

doi:10.1007/BF01324698

A sequential cell kinetic study of meningioma cells in primary explant culture using bromodeoxyuridine

Kusum Kharbanda, Asis K. Karak, Chitra Sarkar, Amit K. Dinda, Meera Mathur, S. Roy

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Abstract

The present study was undertaken to evaluate the sequential BrdU-LI at weekly intervals upto four weeks in 18 primary explant cultures of meningiomas. This revealed three distinct patterns of growth which could be arbitrarily defined as 'degenerating' (group I), 'proliferating' (group II) and 'adaptive' (group III) types. Interestingly two cases of malignant and two of recurrent meningiomas fell into the 'degenerating' group I pattern. The possible explanations for the observed relatively higher in vitro LI values compared to lower in vivo values as reported in the literature and the theoretical implications of the three distinct patterns of sequential LI values are discussed.

Original language	English (US)
Pages (from-to)	117-123
Number of pages	7
Journal	Journal of Neuro-Oncology
Volume	16
Issue number	2
DOIs	https://doi.org/10.1007/BF01324698
State	Published - Jun 1993
Externally published	Yes

Keywords

bromodeoxyuridine
histological types
malignant
meningioma
primary cultures
recurrent
sequential labeling index

ASJC Scopus subject areas

Oncology
Neurology
Clinical Neurology
Cancer Research

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10.1007/BF01324698

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title = "A sequential cell kinetic study of meningioma cells in primary explant culture using bromodeoxyuridine",

abstract = "The present study was undertaken to evaluate the sequential BrdU-LI at weekly intervals upto four weeks in 18 primary explant cultures of meningiomas. This revealed three distinct patterns of growth which could be arbitrarily defined as 'degenerating' (group I), 'proliferating' (group II) and 'adaptive' (group III) types. Interestingly two cases of malignant and two of recurrent meningiomas fell into the 'degenerating' group I pattern. The possible explanations for the observed relatively higher in vitro LI values compared to lower in vivo values as reported in the literature and the theoretical implications of the three distinct patterns of sequential LI values are discussed.",

keywords = "bromodeoxyuridine, histological types, malignant, meningioma, primary cultures, recurrent, sequential labeling index",

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T1 - A sequential cell kinetic study of meningioma cells in primary explant culture using bromodeoxyuridine

AU - Kharbanda, Kusum

AU - Karak, Asis K.

AU - Sarkar, Chitra

AU - Dinda, Amit K.

AU - Mathur, Meera

AU - Roy, S.

PY - 1993/6

Y1 - 1993/6

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AB - The present study was undertaken to evaluate the sequential BrdU-LI at weekly intervals upto four weeks in 18 primary explant cultures of meningiomas. This revealed three distinct patterns of growth which could be arbitrarily defined as 'degenerating' (group I), 'proliferating' (group II) and 'adaptive' (group III) types. Interestingly two cases of malignant and two of recurrent meningiomas fell into the 'degenerating' group I pattern. The possible explanations for the observed relatively higher in vitro LI values compared to lower in vivo values as reported in the literature and the theoretical implications of the three distinct patterns of sequential LI values are discussed.

KW - bromodeoxyuridine

KW - histological types

KW - malignant

KW - meningioma

KW - primary cultures

KW - recurrent

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A sequential cell kinetic study of meningioma cells in primary explant culture using bromodeoxyuridine

Abstract

Keywords

ASJC Scopus subject areas

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