A simple correlation for predicting effective diffusivities in immobilized cell systems

Mark R. Riley, Fernando J. Muzzio, Helen M. Buettner, Sebastian C. Reyes

Research output: Contribution to journalArticle

47 Scopus citations

Abstract

A simple correlation method has been developed to predict effective diffusivities of small molecules in heterogeneous materials such as immobilized cell systems. This correlation uses a single diffusivity measurement at one cell volume fraction to predict diffusivities for any other volume fraction of cells. The method has been applied to 20 sets of published diffusivity measurements in immobilized cell systems and accurately predicts effective diffusivities of molecules for the full range of cell fractions. It may also be used to predict effective diffusivities in heterogeneous materials in which the diffusivity of a molecule in each phase and the volume fraction of each phase are known.

Original languageEnglish (US)
Pages (from-to)223-227
Number of pages5
JournalBiotechnology and Bioengineering
Volume49
Issue number2
DOIs
StatePublished - Jan 20 1996

Keywords

  • diffusivity measurement
  • immobilized cells

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology

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