A single case of Rosai-Dorfman disease marked by pathologic fractures, kidney failure, and liver cirrhosis treated with single-agent cladribine

Koji Sasaki, Naveen Pemmaraju, Jason R. Westin, Wei Lien Wang, Joseph D. Khoury, Donald A. Podoloff, Bryan Moon, Naval Daver, Gautam Borthakur

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Rosai-Dorfman disease (RDD) is a proliferative histiocytic disorder of unknown etiology, which is characterized by sinus histiocytosis with massive lymphadenopathy (1). In most cases, RDD has a benign course and treatment is not necessary. However, severe cases of RDD require treatment, and the treatment strategy is determined on the basis of the severity of the disease or the extranodal involvement of vital organs. We report a single case of RDD with atypical presentation of persistent constitutional symptoms, progressing pathologic fractures, and end-organ dysfunction, including acute kidney failure and liver cirrhosis with esophageal varices.

Original languageEnglish (US)
Article number297
JournalFrontiers in Oncology
Volume4
Issue numberOCT
DOIs
StatePublished - 2014
Externally publishedYes

Keywords

  • CD163
  • Cladribine
  • Histiocytes
  • Rosai-Dorfman disease
  • S-100

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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