A Smoking Cessation Trial with Lobeline Sulfate: A Pilot Study

Elbert D. Glover, Scott J. Leischow, Stephen I. Rennard, Penny N. Glover, David Daughton, John N. Quiring, F. Howard Schneider, Peter J. Mione

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Objective: To evaluate a sublingual formulation of lobeline sulfate for smoking cessation. Methods: Random assignment of 180 healthy smokers to treatment (n=90) or placebo (n=90). Treatment was self-administering a 7.5 mg lobeline sulfate sublingual or placebo tablet 9 times per day for 6 weeks. Results: No difference in cessation efficacy between placebo and active treatment. Among highly dependent smokers who completed the trial, there was a trend for higher cessation rates in the active group. Conclusion: This pilot study failed to demonstrate smoking-cessation efficacy. However, data suggest continued studies to evaluate lobeline sulfate for smoking cessation.

Original languageEnglish (US)
Pages (from-to)62-74
Number of pages13
JournalAmerican Journal of Health Behavior
Issue number1
StatePublished - Jan 1998

ASJC Scopus subject areas

  • Health(social science)
  • Social Psychology
  • Public Health, Environmental and Occupational Health


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