A SPLINE-BASED NONPARAMETRIC ANALYSIS FOR INTERVAL-CENSORED BIVARIATE SURVIVAL DATA

Yuan Wu, Ying Zhang, Junyi Zhou

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

In this manuscript, we propose a spline-based sieve nonparametric maximum likelihood estimation method for a joint distribution function with bivariate interval-censored data. We study the asymptotic behavior of the proposed estimator by proving the consistency and deriving the rate of convergence. Based on the sieve estimate of the joint distribution, we also develop an efficient nonparametric test for making inferences about the dependence between two interval-censored event times and establish its asymptotic normality. We conduct simulation studies to examine the finite-sample performance of the proposed methodology. Finally, we apply the method to assess the association between two subtypes of mild cognitive impairment (MCI), amnestic MCI and non-amnestic MCI, for Huntington’s disease (HD) using data from a 12-year observational cohort study on premanifest HD individuals, PREDICT-HD.

Original languageEnglish (US)
Pages (from-to)1541-1562
Number of pages22
JournalStatistica Sinica
Volume32
Issue number3
DOIs
StatePublished - Jul 2022

Keywords

  • Empirical process
  • generalized gradient projection algorithm
  • sieve estimation

ASJC Scopus subject areas

  • Statistics and Probability
  • Statistics, Probability and Uncertainty

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