A survey of cytosine and cytidine salvage in fungi

Rajiv K. Kulkarni, Joseph A. Krzycki, Kenneth W. Nickerson

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Twenty-five fungi, including representatives from each of the four major classes, were surveyed with regard to their ability to utilize exogenous cytosine and cytidine. Two assay methods were employed: incorporation of radiolabeled precursors and sensitivity to 5-fluorinated structural analogs. The following taxonomic correlations were found: (i) the Ascomycetes utilize exogenous cytidine and/or cytosine; (ii) the lower fungi utilize cytidine but not cytosine; (iii) the Basidiomycetes utilize neither; and (iv) the Dueteromycetes, with some exceptions, closely resemble the Ascomycetes. Additionally, natural resistance to 5-fluorocytosine via both defective transport and pyrimidine excretion was observed.

Original languageEnglish (US)
Pages (from-to)116-122
Number of pages7
JournalExperimental Mycology
Volume4
Issue number2
DOIs
StatePublished - Jun 1980

Keywords

  • 5-fluorocytosine
  • cytosine salvage
  • fungal taxonomy
  • pyrimidine excretion

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology

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