A systematic review and network meta-analysis of injectable antibiotic options for the control of bovine respiratory disease in the first 45 days post arrival at the feedlot

A. M. O'connor, D. Hu, S. C. Totton, N. Scott, C. B. Winder, B. Wang, C. Wang, J. Glanville, H. Wood, B. White, R. Larson, C. Waldner, J. M. Sargeant

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

We conducted a systematic review and network meta-analysis to determine the comparative efficacy of antibiotics used to control bovine respiratory disease (BRD) in beef cattle on feedlots. The information sources for the review were: MEDLINE®, MEDLINE In-Process and MEDLINE® Daily, AGRICOLA, Epub Ahead of Print, Cambridge Agricultural and Biological Index, Science Citation Index, Conference Proceedings Citation Index - Science, the Proceedings of the American Association of Bovine Practitioners, World Buiatrics Conference, and the United States Food and Drug Administration Freedom of Information New Animal Drug Applications summaries. The eligible population was weaned beef cattle raised in intensive systems. The interventions of interest were injectable antibiotics used at the time the cattle arrived at the feedlot. The outcome of interest was the diagnosis of BRD within 45 days of arrival at the feedlot. The network meta-analysis included data from 46 studies and 167 study arms identified in the review. The results suggest that macrolides are the most effective antibiotics for the reduction of BRD incidence. Injectable oxytetracycline effectively controlled BRD compared with no antibiotics; however, it was less effective than macrolide treatment. Because oxytetracycline is already commonly used to prevent, control, and treat BRD in groups of feedlot cattle, the use of injectable oxytetracycline for BRD control might have advantages from an antibiotic stewardship perspective.

Original languageEnglish (US)
Pages (from-to)163-181
Number of pages19
JournalAnimal health research reviews
Volume20
Issue number2
DOIs
StatePublished - Dec 1 2019

Keywords

  • Antibiotics
  • bovine
  • meta-analysis
  • respiratory disease
  • systematic review

ASJC Scopus subject areas

  • Animal Science and Zoology

Fingerprint Dive into the research topics of 'A systematic review and network meta-analysis of injectable antibiotic options for the control of bovine respiratory disease in the first 45 days post arrival at the feedlot'. Together they form a unique fingerprint.

  • Cite this

    O'connor, A. M., Hu, D., Totton, S. C., Scott, N., Winder, C. B., Wang, B., Wang, C., Glanville, J., Wood, H., White, B., Larson, R., Waldner, C., & Sargeant, J. M. (2019). A systematic review and network meta-analysis of injectable antibiotic options for the control of bovine respiratory disease in the first 45 days post arrival at the feedlot. Animal health research reviews, 20(2), 163-181. https://doi.org/10.1017/S1466252320000031