TY - JOUR
T1 - A systematic review and secondary data analysis of the interactions between the serotonin transporter 5-HTTLPR polymorphism and environmental and psychological factors in eating disorders
AU - Rozenblat, Vanja
AU - Ong, Deborah
AU - Fuller-Tyszkiewicz, Matthew
AU - Akkermann, Kirsti
AU - Collier, David
AU - Engels, Rutger C.M.E.
AU - Fernandez-Aranda, Fernando
AU - Harro, Jaanus
AU - Homberg, Judith R.
AU - Karwautz, Andreas
AU - Kiive, Evelyn
AU - Klump, Kelly L.
AU - Larson, Christine L.
AU - Racine, Sarah E.
AU - Richardson, Jodie
AU - Steiger, Howard
AU - Stoltenberg, Scott F.
AU - van Strien, Tatjana
AU - Wagner, Gudrun
AU - Treasure, Janet
AU - Krug, Isabel
N1 - Funding Information:
Financial support was received from the European Union (Framework-V Mutlicenter Research Grant, QK1-1999-916 ), the University of Melbourne Early Career Researcher Grants Scheme (2014, 1350035 ), U.S. National Institute of Mental Health ( 1R15MH077654-01A1 ), the Estonian Ministry of Education and Science ( IUT20-40 and IUT 42-2 ), the National Institute of Health and Michigan State University ( T32-MH070343 and #05-IRGP-883 ), the Quebec government's Joint CQRS-FRSQ-MSSS Program in Mental Health ( SR-4306 ), the Canadian Institute of Health Research ( MOP-57929 ), the Dutch Organization for Scientific Research (no. 400-05-051 ) and the Radboud University Nijmegen . None of these institutions had any role in the study design, collection, analysis and interpretation of data, preparation of the manuscript, or decision to submit the manuscript for publication.
Publisher Copyright:
© 2016 Elsevier Ltd
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Objectives To summarize and synthesize the growing gene x environment (GxE) research investigating the promoter region of the serotonin transporter gene (5-HTTLPR) in the eating disorders (ED) field, and overcome the common limitation of low sample size, by undertaking a systematic review followed by a secondary data meta-analysis of studies identified by the review. Method A systematic review of articles using PsycINFO, PubMed, and EMBASE was undertaken to identify studies investigating the interaction between 5-HTTLPR and an environmental or psychological factor, with an ED-related outcome variable. Seven studies were identified by the systematic review, with complete data sets of five community (n = 1750, 64.5% female) and two clinical (n = 426, 100% female) samples combined to perform four secondary-data analyses: 5-HTTLPR x Traumatic Life Events to predict ED status (n = 909), 5-HTTLPR x Sexual and Physical Abuse to predict bulimic symptoms (n = 1097), 5-HTTLPR x Depression to predict bulimic symptoms (n = 1256), and 5-HTTLPR x Impulsiveness to predict disordered eating (n = 1149). Results Under a multiplicative model, the low function (s) allele of 5-HTTLPR interacted with traumatic life events and experiencing both sexual and physical abuse (but not only one) to predict increased likelihood of an ED and bulimic symptoms, respectively. However, under an additive model there was also an interaction between sexual and physical abuse considered independently and 5-HTTLPR, and no interaction with traumatic life events. No other GxE interactions were significant. Conclusion Early promising results should be followed-up with continued cross-institutional collaboration in order to achieve the large sample sizes necessary for genetic research.
AB - Objectives To summarize and synthesize the growing gene x environment (GxE) research investigating the promoter region of the serotonin transporter gene (5-HTTLPR) in the eating disorders (ED) field, and overcome the common limitation of low sample size, by undertaking a systematic review followed by a secondary data meta-analysis of studies identified by the review. Method A systematic review of articles using PsycINFO, PubMed, and EMBASE was undertaken to identify studies investigating the interaction between 5-HTTLPR and an environmental or psychological factor, with an ED-related outcome variable. Seven studies were identified by the systematic review, with complete data sets of five community (n = 1750, 64.5% female) and two clinical (n = 426, 100% female) samples combined to perform four secondary-data analyses: 5-HTTLPR x Traumatic Life Events to predict ED status (n = 909), 5-HTTLPR x Sexual and Physical Abuse to predict bulimic symptoms (n = 1097), 5-HTTLPR x Depression to predict bulimic symptoms (n = 1256), and 5-HTTLPR x Impulsiveness to predict disordered eating (n = 1149). Results Under a multiplicative model, the low function (s) allele of 5-HTTLPR interacted with traumatic life events and experiencing both sexual and physical abuse (but not only one) to predict increased likelihood of an ED and bulimic symptoms, respectively. However, under an additive model there was also an interaction between sexual and physical abuse considered independently and 5-HTTLPR, and no interaction with traumatic life events. No other GxE interactions were significant. Conclusion Early promising results should be followed-up with continued cross-institutional collaboration in order to achieve the large sample sizes necessary for genetic research.
KW - 5-HTTLPR
KW - Bulimia nervosa
KW - Eating disorders
KW - Gene-environment interaction
KW - Meta-analysis
KW - Systematic review
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U2 - 10.1016/j.jpsychires.2016.09.023
DO - 10.1016/j.jpsychires.2016.09.023
M3 - Review article
C2 - 27701012
AN - SCOPUS:84988917482
SN - 0022-3956
VL - 84
SP - 62
EP - 72
JO - Journal of Psychiatric Research
JF - Journal of Psychiatric Research
ER -