TY - JOUR
T1 - A toxicity study of cyclophosphamide in combination induction therapy in childhood acute lymphocytic leukemia
T2 - A report for childrens cancer study group
AU - Gross, Samuel
AU - Siegel, Stuart
AU - Coccia, Peter
AU - Bleyer, W. Archie
AU - Hammond, D.
PY - 1980
Y1 - 1980
N2 - In a CCSG study, the addition of cyclophosphamide to L-asparaginase, vincristine, and predni-sone (C-OPA) did not add a major toxic burden or deter from induction efficiency when compared to L-asparaginase, vincristine, and prednisone (OPA) for average and poor prognosis children with acute lymphocytic leukemia. At the end of 56 days, death rates and complete remission rates were identical in both groups. Although there was more major toxicity, i.e., three septicemic episodes in the C-OPA group versus one in the OPA group, there were no resultant deaths, and the overall frequency of infection was the same in both groups.
AB - In a CCSG study, the addition of cyclophosphamide to L-asparaginase, vincristine, and predni-sone (C-OPA) did not add a major toxic burden or deter from induction efficiency when compared to L-asparaginase, vincristine, and prednisone (OPA) for average and poor prognosis children with acute lymphocytic leukemia. At the end of 56 days, death rates and complete remission rates were identical in both groups. Although there was more major toxicity, i.e., three septicemic episodes in the C-OPA group versus one in the OPA group, there were no resultant deaths, and the overall frequency of infection was the same in both groups.
UR - http://www.scopus.com/inward/record.url?scp=0019277135&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019277135&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0019277135
SN - 0192-8562
VL - 2
SP - 321
EP - 325
JO - American Journal of Pediatric Hematology/Oncology
JF - American Journal of Pediatric Hematology/Oncology
IS - 4
ER -