A toxicity study of cyclophosphamide in combination induction therapy in childhood acute lymphocytic leukemia: A report for childrens cancer study group

Samuel Gross, Stuart Siegel, Peter Coccia, W. Archie Bleyer, D. Hammond

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

In a CCSG study, the addition of cyclophosphamide to L-asparaginase, vincristine, and predni-sone (C-OPA) did not add a major toxic burden or deter from induction efficiency when compared to L-asparaginase, vincristine, and prednisone (OPA) for average and poor prognosis children with acute lymphocytic leukemia. At the end of 56 days, death rates and complete remission rates were identical in both groups. Although there was more major toxicity, i.e., three septicemic episodes in the C-OPA group versus one in the OPA group, there were no resultant deaths, and the overall frequency of infection was the same in both groups.

Original languageEnglish (US)
Pages (from-to)321-325
Number of pages5
JournalAmerican Journal of Pediatric Hematology/Oncology
Volume2
Issue number4
StatePublished - 1980

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

Fingerprint

Dive into the research topics of 'A toxicity study of cyclophosphamide in combination induction therapy in childhood acute lymphocytic leukemia: A report for childrens cancer study group'. Together they form a unique fingerprint.

Cite this