A twin and family study of the association between immune system dysfunction and dyslexia using blood serum immunoassay and survey data

Jeffrey W. Gilger, Bruce F. Pennington, Ronald J. Harbeck, John C. Defries, Brian Kotzin, Phyllis Green, Shelley Smith

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

We conducted a study of the association between developmental reading disability (DRD) and immune disorders (ID) using both survey and immunoassay data in tWO separate samples of families. One sample was made up of twins and their parents and was ascertained through a population-based sampling scheme. The other sample was a set of extended pedigrees selected for apparent autosomal dominant transmission of DRD. We failed to find an association between DRD and ID in either sample, regardless of the method used to assess immune system function. Even though our twin sample provided evidence that both DRD and immune conditions were significantly heritable, there was no evidence for a genetic correlation between ID and DRD nor was there any clear indication that a special subgroup of individuals may be comorbid for these conditions because of genetic reasons. How these negative findings can be reconciled with the developmental hypothesis of Geschwind, Behan, Galaburda, and colleagues, and how they may relate to the gene locus influencing DRD that has been recently located in the HLA region of the short aim of chromosome 6 is discussed.

Original languageEnglish (US)
Pages (from-to)310-333
Number of pages24
JournalBrain and Cognition
Volume36
Issue number3
DOIs
StatePublished - Apr 1998
Externally publishedYes

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Experimental and Cognitive Psychology
  • Developmental and Educational Psychology
  • Arts and Humanities (miscellaneous)
  • Cognitive Neuroscience

Fingerprint Dive into the research topics of 'A twin and family study of the association between immune system dysfunction and dyslexia using blood serum immunoassay and survey data'. Together they form a unique fingerprint.

  • Cite this