Aberrant high-gamma oscillations in the somatosensory cortex of children with cerebral palsy: A meg study

Xinyao Guo, Jing Xiang, Sheila Mun-Bryce, Marcus Bryce, Samuel Huang, Xiaolin Huo, Yingying Wang, Douglas Rose, Ton Degrauw, Kristen Gartner, Tianbao Song, Jennifer Schmit, Jilda Vargus-Adams

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Objective: Our study is to investigate somatosensory dysfunction in children with spastic cerebral palsy (CP) using magnetoencephalography (MEG) and synthetic aperture magnetometry (SAM). Methods: Six children with spastic CP and six age- and gender-matched typically developing children were studied using a 275-channel MEG system while their left and right index fingers were stimulated in random order. The latency and amplitude of somatosensory evoked magnetic fields were analyzed at sensor level. The patterns of high-gamma oscillations were investigated with SAM at source level. Results: In comparison to the children with typical development, the latency of the first response of somatosensory evoked magnetic fields (SEFs) in the children with spastic CP was significantly delayed (p<0.05). High-gamma oscillations were identified in the somatosensory cortex in both children with CP and typical developing children. Interestingly, children with spastic CP had significantly higher incidence of ipsilateral activation in the somatosensory cortex following right and left finger stimulation, compared to typically developing children (p=0.05). Conclusion: The results suggest that children with spastic CP have a measurable delay of SEFs and high-gamma oscillations. The high rates of ipsilateral cortical activation imply the impairments of functional lateralization in the developing brain. This is the first MEG study to demonstrate abnormal high-gamma oscillations of somatosensory cortices representing the finger in children with spastic CP.

Original languageEnglish (US)
Pages (from-to)576-583
Number of pages8
JournalBrain and Development
Volume34
Issue number7
DOIs
StatePublished - Aug 1 2012

Keywords

  • Cerebral palsy
  • Children
  • High-gamma oscillations
  • Magnetoencephalography
  • Somatosensory

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Clinical Neurology

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    Guo, X., Xiang, J., Mun-Bryce, S., Bryce, M., Huang, S., Huo, X., Wang, Y., Rose, D., Degrauw, T., Gartner, K., Song, T., Schmit, J., & Vargus-Adams, J. (2012). Aberrant high-gamma oscillations in the somatosensory cortex of children with cerebral palsy: A meg study. Brain and Development, 34(7), 576-583. https://doi.org/10.1016/j.braindev.2011.09.012