Abnormal mitochondrial dynamics-a novel therapeutic target for alzheimer's disease?

Bo Su, Xinglong Wang, David Bonda, Gorge Perry, Mark Smith, Xiongwei Zhu

Research output: Contribution to journalArticlepeer-review

60 Scopus citations

Abstract

Mitochondria are dynamic organelles that undergo continuous fission and fusion, which could affect all aspects of mitochondrial function. Mitochondrial dysfunction has been well documented in Alzheimer's disease (AD). In the past few years, emerging evidence indicates that an imbalance of mitochondrial dynamics is involved in the pathogenesis of AD. In this review, we discuss in detail the abnormal mitochondrial dynamics in AD and how such abnormal dynamics may impact mitochondrial and neuronal function and contribute to the course of disease. Based on this discussion, we propose that mitochondrial dynamics could be a potential therapeutic target for AD.

Original languageEnglish (US)
Pages (from-to)87-96
Number of pages10
JournalMolecular Neurobiology
Volume41
Issue number2-3
DOIs
StatePublished - Jun 2010
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Dimebon
  • Drug
  • Mitochondrial dynamics
  • Mitochondrial fission
  • Mitochondrial fusion

ASJC Scopus subject areas

  • Neurology
  • Cellular and Molecular Neuroscience

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