Abnormal mitochondrial dynamics and neurodegenerative diseases

Bo Su, Xinglong Wang, Ling Zheng, George Perry, Mark A. Smith, Xiongwei Zhu

Research output: Contribution to journalReview articlepeer-review

194 Scopus citations

Abstract

Mitochondrial dysfunction is a prominent feature of various neurodegenerative diseases. A deeper understanding of the remarkably dynamic nature of mitochondria, characterized by a delicate balance of fission and fusion, has helped to fertilize a recent wave of new studies demonstrating abnormal mitochondrial dynamics in neurodegenerative diseases. This review highlights mitochondrial dysfunction and abnormal mitochondrial dynamics in Alzheimer disease, Parkinson disease, amyotrophic lateral sclerosis, and Huntington disease and discusses how these abnormal mitochondrial dynamics may contribute to mitochondrial and neuronal dysfunction. We propose that abnormal mitochondrial dynamics represents a key common pathway that mediates or amplifies mitochondrial dysfunction and neuronal dysfunction during the course of neurodegeneration.

Original languageEnglish (US)
Pages (from-to)135-142
Number of pages8
JournalBiochimica et Biophysica Acta - Molecular Basis of Disease
Volume1802
Issue number1
DOIs
StatePublished - Jan 2010
Externally publishedYes

Keywords

  • Alzheimer disease
  • DLP1/Drp1
  • Mitochondrial distribution
  • Mitochondrial dynamics
  • Mitochondrial dysfunction
  • Parkinson disease
  • Synaptic dysfunction

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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