Abnormal mitochondrial dynamics in the pathogenesis of Alzheimer's disease

Xiongwei Zhu, George Perry, Mark A. Smitha, Xinglong Wang

Research output: Contribution to journalReview articlepeer-review

112 Scopus citations

Abstract

Mitochondrial dysfunction is one of the most early and prominent features in vulnerable neurons in the brain of Alzheimer's disease (AD) patients. Recent studies suggest that mitochondria are highly dynamic organelles characterized by a delicate balance of fission and fusion, a concept that has revolutionized our basic understanding of the regulation of mitochondrial structure and function which has far-reaching significance in studies of health and disease. Tremendous progress has been made in studying changes in mitochondrial dynamics in AD brain and models and the potential underlying mechanisms. This review highlights the recent work demonstrating abnormal mitochondrial dynamics and distribution in AD models and discusses how these abnormalities may contribute to various aspects of mitochondrial dysfunction and the pathogenesis of AD.

Original languageEnglish (US)
Pages (from-to)S253-S262
JournalJournal of Alzheimer's Disease
Volume33
Issue numberSUPPL. 1
DOIs
StatePublished - 2013
Externally publishedYes

Keywords

  • Alzheimer's disease
  • mitochondrial distribution
  • mitochondrial dynamics
  • mitochondrial dysfunction
  • mitochondrial fission
  • mitochondrial fusion

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

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