Abnormalities involving chromosome 6 in newly diagnosed patients with non-Hodgkin's lymphoma

Harry C. Schouten, Warren G. Sanger, Dennis D. Weisenburger, James O. Armitage

Research output: Contribution to journalArticle

47 Scopus citations

Abstract

Several cytogenetic abnormalities involving chromosome 6 occurring in Non-Hodgkin's lymphoma (NHL) have been described. We report 34 newly diagnosed patients with NHL who had an abnormal chromosome 6 on initial biopsy. Monosomies (n = 5), trisomies (n = 6), deletions of 6q (n = 13), and isochromosomes 6p (n = 9) were frequently observed and translocations were rare. As compared with 70 other NHL patients with cytogenetic abnormalities, the patients with an abnormal chromosome 6 had a higher frequency of immunoblastic lymphoma (p < 0.001). These patients also were more likely to have B symptoms (p = 0.02). Patients with a breakpoint at 6q11-16 all had a deletion of the distal portion and also were more likely to have B symptoms (p < 0.001). Most patients with breakpoints at 6q21-25 had a deletion associated with a lower frequency of stage IV disease (p = 0.03) and a higher complete remission (CR) rate (p = 0.03). The patients with an i(6p) had a lower frequency of stage IV disease (p = 0.03), and the patients with a trisomy 6 had a shorter median survival (p = 0.005). Our results suggest that chromosome 6, especially the long arm, carries important information for the clinical behavior of NHL. Future studies are necessary to resolve the molecular defects.

Original languageEnglish (US)
Pages (from-to)73-82
Number of pages10
JournalCancer genetics and cytogenetics
Volume47
Issue number1
DOIs
StatePublished - Jul 1 1990

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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