Accelerated development of chronic lymphocytic leukemia in New Zealand black mice expressing a low level of interferon regulatory factor 4

Shibin Ma, Vipul Shukla, Leilei Fang, Karen A. Gould, Shantaram S. Joshi, Runqing Lu

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Background: A genome-wide SNP association study has linked low levels of IRF4 with the development of CLL. Results: Low levels of IRF4 disrupt homeostasis of B1 B cells and promote survival of CLL cell. Conclusion: Our results demonstrate a causal relationship between low levels of IRF4 and the development of CLL. Significance: We establish IRF4 as a critical regulator in the pathogenesis of CLL.

Original languageEnglish (US)
Pages (from-to)26430-26440
Number of pages11
JournalJournal of Biological Chemistry
Volume288
Issue number37
DOIs
StatePublished - Sep 13 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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