Accelerated development of chronic lymphocytic leukemia in New Zealand black mice expressing a low level of interferon regulatory factor 4

Shibin Ma; Vipul Shukla; Leilei Fang; Karen A. Gould; Shantaram S. Joshi; Runqing Lu

doi:10.1074/jbc.M113.475913

Accelerated development of chronic lymphocytic leukemia in New Zealand black mice expressing a low level of interferon regulatory factor 4

Shibin Ma, Vipul Shukla, Leilei Fang, Karen A. Gould, Shantaram S. Joshi, Runqing Lu

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Background: A genome-wide SNP association study has linked low levels of IRF4 with the development of CLL. Results: Low levels of IRF4 disrupt homeostasis of B1 B cells and promote survival of CLL cell. Conclusion: Our results demonstrate a causal relationship between low levels of IRF4 and the development of CLL. Significance: We establish IRF4 as a critical regulator in the pathogenesis of CLL.

Original language	English (US)
Pages (from-to)	26430-26440
Number of pages	11
Journal	Journal of Biological Chemistry
Volume	288
Issue number	37
DOIs	https://doi.org/10.1074/jbc.M113.475913
State	Published - Sep 13 2013

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.M113.475913

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title = "Accelerated development of chronic lymphocytic leukemia in New Zealand black mice expressing a low level of interferon regulatory factor 4",

abstract = "Background: A genome-wide SNP association study has linked low levels of IRF4 with the development of CLL. Results: Low levels of IRF4 disrupt homeostasis of B1 B cells and promote survival of CLL cell. Conclusion: Our results demonstrate a causal relationship between low levels of IRF4 and the development of CLL. Significance: We establish IRF4 as a critical regulator in the pathogenesis of CLL.",

author = "Shibin Ma and Vipul Shukla and Leilei Fang and Gould, {Karen A.} and Joshi, {Shantaram S.} and Runqing Lu",

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T1 - Accelerated development of chronic lymphocytic leukemia in New Zealand black mice expressing a low level of interferon regulatory factor 4

AU - Ma, Shibin

AU - Shukla, Vipul

AU - Fang, Leilei

AU - Gould, Karen A.

AU - Joshi, Shantaram S.

AU - Lu, Runqing

PY - 2013/9/13

Y1 - 2013/9/13

N2 - Background: A genome-wide SNP association study has linked low levels of IRF4 with the development of CLL. Results: Low levels of IRF4 disrupt homeostasis of B1 B cells and promote survival of CLL cell. Conclusion: Our results demonstrate a causal relationship between low levels of IRF4 and the development of CLL. Significance: We establish IRF4 as a critical regulator in the pathogenesis of CLL.

AB - Background: A genome-wide SNP association study has linked low levels of IRF4 with the development of CLL. Results: Low levels of IRF4 disrupt homeostasis of B1 B cells and promote survival of CLL cell. Conclusion: Our results demonstrate a causal relationship between low levels of IRF4 and the development of CLL. Significance: We establish IRF4 as a critical regulator in the pathogenesis of CLL.

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JO - Journal of Biological Chemistry

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IS - 37

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Accelerated development of chronic lymphocytic leukemia in New Zealand black mice expressing a low level of interferon regulatory factor 4

Abstract

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