TY - JOUR
T1 - Accurate prediction of nodal status in preoperative patients with pancreatic ductal adenocarcinoma using next-gen nanoparticle
AU - McDermott, Shaunagh
AU - Thayer, Sarah P.
AU - Castillo, Carlos Fernandez Del
AU - Mino-Kenudson, Mari
AU - Weissleder, Ralph
AU - Harisinghani, Mukesh G.
N1 - Funding Information:
Address all correspondence to: Shaunagh McDermott, MB, BCh, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114. E-mail: [email protected] 1We thank GI Spore for financial support. Received 14 May 2013; Revised 21 August 2013; Accepted 23 August 2013 Copyright © 2013 Neoplasia Press, Inc. Open access under CC BY-NC-ND license. 1944-7124/13 DOI 10.1593/tlo.13400
PY - 2013/12
Y1 - 2013/12
N2 - Objective: The objective of this study is to assess lymphotropic nanoparticle-enhanced magnetic resonance imaging (LNMRI) in identifying malignant nodal involvement in patients with pancreatic ductal adenocarcinoma. Methods: Magnetic resonance imaging was performed in 13 patients with known or high index of suspicion of pancreatic cancer and who were scheduled for surgical resection. Protocols included T2*-weighted imaging before and after administration of Ferumoxytol (Feraheme) for the evaluation of lymph node involvement. Eleven of the 13 patients underwent a Whipple procedure and lymph node dissection. Nodes that lacked contrast uptake were deemed malignant, and those that demonstrated homogeneous uptake were deemed benign. Results: A total of 264 lymph nodes were resection, of which 17 were malignant. The sensitivity and specificity of LNMRI was 76.5% and 98.4%at a nodal level and 83.3%and 80%at a patient level. Conclusion: LNMRI demonstrated high sensitivity and specificity in patients with pancreatic ductal adenocarcinoma.
AB - Objective: The objective of this study is to assess lymphotropic nanoparticle-enhanced magnetic resonance imaging (LNMRI) in identifying malignant nodal involvement in patients with pancreatic ductal adenocarcinoma. Methods: Magnetic resonance imaging was performed in 13 patients with known or high index of suspicion of pancreatic cancer and who were scheduled for surgical resection. Protocols included T2*-weighted imaging before and after administration of Ferumoxytol (Feraheme) for the evaluation of lymph node involvement. Eleven of the 13 patients underwent a Whipple procedure and lymph node dissection. Nodes that lacked contrast uptake were deemed malignant, and those that demonstrated homogeneous uptake were deemed benign. Results: A total of 264 lymph nodes were resection, of which 17 were malignant. The sensitivity and specificity of LNMRI was 76.5% and 98.4%at a nodal level and 83.3%and 80%at a patient level. Conclusion: LNMRI demonstrated high sensitivity and specificity in patients with pancreatic ductal adenocarcinoma.
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U2 - 10.1593/tlo.13400
DO - 10.1593/tlo.13400
M3 - Article
C2 - 24466369
AN - SCOPUS:84891704327
SN - 1944-7124
VL - 6
SP - 670
EP - 675
JO - Translational Oncology
JF - Translational Oncology
IS - 6
ER -