Achievement of cellular immunity and discordant xenogeneic tolerance in mice by porcine thymus grafts.

Yong Zhao, Zuyue Sun, Yimin Sun, Alan N. Langnas

Research output: Contribution to journalReview article

6 Scopus citations

Abstract

Specific cellular immune tolerance may be essential for successful xenotransplantation in humans. Thymectomized (ATX), T and NK cell-depleted immunocompetent mice grafted with xenogeneic fetal pig thymic and liver tissue (FP THY/LIV) result in efficient mouse thymopoiesis and peripheral repopulation of functional mouse CD4(+) T cell. Very importantly, the reconstituted mouse T cells are specifically tolerant to pig donor antigens. Studies demonstrated that porcine MHCs mediated positive and negative selection of mouse thymocytes in FP THY grafts, whereas mouse MHCs were involved in negative selection in grafts. Therefore, T cell tolerance to xenogeneic donor antigens could be induced by grafting donor thymus tissue. Xenogeneic thymic replacement might have a potential role in the reconstitution of cellular immunity in patients with AIDS or other immunodeficiencies caused by thymus dysfunction.

Original languageEnglish (US)
Pages (from-to)173-179
Number of pages7
JournalCellular & molecular immunology
Volume1
Issue number3
StatePublished - Jun 2004

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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