Acid- and base-stable esters: A new protecting group for carboxylic acids

Michio Kurosu; Kallolmay Biswas; Prabagaran Narayanasamy; Dean C. Crick

doi:10.1055/s-2007-983801

Acid- and base-stable esters: A new protecting group for carboxylic acids

Michio Kurosu, Kallolmay Biswas, Prabagaran Narayanasamy, Dean C. Crick

Research output: Contribution to journal › Article

3 Scopus citations

Abstract

An acid- and base-stable protecting group for carboxylic acids is described. The esters of (2,6-dichloro-4-methoxyphenyl)(2,4-dichlorophenyl) methanol are stable to Bransted and Lewis acids, Brønsted bases, and a wide variety of nucleophiles; however, the esters can be conveniently deprotected by a solvolytic displacement reaction with 20% trifluoroacetic acid.

Original language	English (US)
Pages (from-to)	2513-2516
Number of pages	4
Journal	Synthesis
Issue number	16
DOIs	https://doi.org/10.1055/s-2007-983801
State	Published - Aug 16 2007

Keywords

Acid-stable ester
Base-stable ester
Carboxylic acid protecting group
Chlorodiphenylmethyl esters

ASJC Scopus subject areas

Catalysis
Organic Chemistry

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10.1055/s-2007-983801

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Kurosu, M., Biswas, K., Narayanasamy, P., & Crick, D. C. (2007). Acid- and base-stable esters: A new protecting group for carboxylic acids. Synthesis, (16), 2513-2516. https://doi.org/10.1055/s-2007-983801

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