Abstract
An acid- and base-stable protecting group for carboxylic acids is described. The esters of (2,6-dichloro-4-methoxyphenyl)(2,4-dichlorophenyl) methanol are stable to Bransted and Lewis acids, Brønsted bases, and a wide variety of nucleophiles; however, the esters can be conveniently deprotected by a solvolytic displacement reaction with 20% trifluoroacetic acid.
Original language | English (US) |
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Pages (from-to) | 2513-2516 |
Number of pages | 4 |
Journal | Synthesis |
Issue number | 16 |
DOIs | |
State | Published - Aug 16 2007 |
Externally published | Yes |
Keywords
- Acid-stable ester
- Base-stable ester
- Carboxylic acid protecting group
- Chlorodiphenylmethyl esters
ASJC Scopus subject areas
- Catalysis
- Organic Chemistry