ACR appropriateness criteria® advanced stage endometrial cancer

Mohamed A. Elshaikh, Catheryn M. Yashar, Aaron H. Wolfson, Higinia Rosa Cardenes, Beth Erickson, Anuja Jhingran, Shruti Jolly, Elizabeth Kidd, Larissa J. Lee, Nina A. Mayr, David Moore, Gautam G. Rao, William Small, Mahesh A. Varia, Andrew O. Wahl, William Yuh, David K. Gaffney

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


OBJECTIVES: Patients with advanced stage endometrial carcinoma constitute a heterogeneous group of patients with different stages, tumor histologic types, and involved sites. Hysterectomy, bilateral salpingo-ophorectomy, and surgical staging are the cornerstone of surgical management in these patients. The optimal adjuvant therapy is yet to be established. An expert panel was convened to reach consensus on the most appropriate management options in this group of patients. METHODS: The American College of Radiology Appropriateness Criteria are evidence-based guidelines for specific clinical conditions that are reviewed every 3 years by a multidisciplinary expert panel. The guideline development and review include an extensive analysis of current medical literature from peer-reviewed journals and the application of a well-established consensus methodology (modified Delphi) to rate the appropriateness of imaging and treatment procedures by the panel. In those instances where evidence is lacking or not definitive, expert opinion may be used to recommend imaging or treatment. RESULTS: Four clinical variants were developed to address common scenarios in the management of women with advanced-stage endometrial carcinoma. Group members reached consensus on the appropriateness of specific evaluation and treatment approaches with numerical ratings. CONCLUSIONS: In combining available medical literature and expert opinions, this manuscript may serve as an aid for other practitioners in the appropriate management of women with advanced-stage endometrial carcinoma.

Original languageEnglish (US)
Pages (from-to)391-396
Number of pages6
JournalAmerican Journal of Clinical Oncology: Cancer Clinical Trials
Issue number4
StatePublished - Aug 2014


  • Advanced stage
  • Appropriateness criteria
  • Chemotherapy
  • Endometrial cancer
  • Multimodality
  • Radiation treatment

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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