ACS chemical neuroscience molecule spotlight on ELND006: Another γ-secretase inhibitor fails in the clinic

Medicine & Life Sciences

• (R)-4-cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1H-pyrazolo(4,3-c)quinoline 100%
• Amyloid Precursor Protein Secretases 52%
• Neurosciences 45%
• N2-((2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl)-N1-((7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo(b,d)azepin-7-yl)-L-alaninamide 39%
• Alzheimer Disease 32%
• Clinical Trials 27%
• Liver 10%

Chemical Compounds

• Molecule 14%