ACTH increases diacylglycerol content and subcellular redistribution of protein kinase C in the rat adrenal in vivo

Robert V. Farese, Luisa F. Fanjul, C. M. de Ruiz Galarreta, John S. Davis, Denise R. Cooper

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Treatment of rats in vivo with ACTH provoked increases in whole adrenal contents of phosphatidylinositol and diacylglycerol. Concomitantly, C-kinase activity decreased in cytosol and increased stoichiometrically in the membrane fraction. It appears that the de novo phospholipid synthesis effect of ACTH is accompanied by increases in diacylglycerol and translocative activation of the C-kinase system.

Original languageEnglish (US)
Pages (from-to)2631-2637
Number of pages7
JournalLife Sciences
Volume41
Issue number24
DOIs
StatePublished - Dec 14 1987

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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