ACTH increases diacylglycerol content and subcellular redistribution of protein kinase C in the rat adrenal in vivo

Robert V. Farese; Luisa F. Fanjul; C. M. de Ruiz Galarreta; John S. Davis; Denise R. Cooper

doi:10.1016/0024-3205(87)90277-3

ACTH increases diacylglycerol content and subcellular redistribution of protein kinase C in the rat adrenal in vivo

Robert V. Farese, Luisa F. Fanjul, C. M. de Ruiz Galarreta, John S. Davis, Denise R. Cooper

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Treatment of rats in vivo with ACTH provoked increases in whole adrenal contents of phosphatidylinositol and diacylglycerol. Concomitantly, C-kinase activity decreased in cytosol and increased stoichiometrically in the membrane fraction. It appears that the de novo phospholipid synthesis effect of ACTH is accompanied by increases in diacylglycerol and translocative activation of the C-kinase system.

Original language	English (US)
Pages (from-to)	2631-2637
Number of pages	7
Journal	Life Sciences
Volume	41
Issue number	24
DOIs	https://doi.org/10.1016/0024-3205(87)90277-3
State	Published - Dec 14 1987
Externally published	Yes

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1016/0024-3205(87)90277-3

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@article{33e525f1ff004298a191b838b104ae69,

title = "ACTH increases diacylglycerol content and subcellular redistribution of protein kinase C in the rat adrenal in vivo",

abstract = "Treatment of rats in vivo with ACTH provoked increases in whole adrenal contents of phosphatidylinositol and diacylglycerol. Concomitantly, C-kinase activity decreased in cytosol and increased stoichiometrically in the membrane fraction. It appears that the de novo phospholipid synthesis effect of ACTH is accompanied by increases in diacylglycerol and translocative activation of the C-kinase system.",

author = "Farese, {Robert V.} and Fanjul, {Luisa F.} and {de Ruiz Galarreta}, {C. M.} and Davis, {John S.} and Cooper, {Denise R.}",

note = "Funding Information: Supported by funds from the Research Service of the Veterans Administration (Drs. Farese & Davis); Spanish American Joint Committee for Scientific and Technological Cooperation (Drs. Fanjul & Galarreta); and NIH Grant HD22248 (Dr. Davis).",

year = "1987",

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day = "14",

doi = "10.1016/0024-3205(87)90277-3",

language = "English (US)",

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pages = "2631--2637",

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T1 - ACTH increases diacylglycerol content and subcellular redistribution of protein kinase C in the rat adrenal in vivo

AU - Farese, Robert V.

AU - Fanjul, Luisa F.

AU - de Ruiz Galarreta, C. M.

AU - Davis, John S.

AU - Cooper, Denise R.

N1 - Funding Information: Supported by funds from the Research Service of the Veterans Administration (Drs. Farese & Davis); Spanish American Joint Committee for Scientific and Technological Cooperation (Drs. Fanjul & Galarreta); and NIH Grant HD22248 (Dr. Davis).

PY - 1987/12/14

Y1 - 1987/12/14

N2 - Treatment of rats in vivo with ACTH provoked increases in whole adrenal contents of phosphatidylinositol and diacylglycerol. Concomitantly, C-kinase activity decreased in cytosol and increased stoichiometrically in the membrane fraction. It appears that the de novo phospholipid synthesis effect of ACTH is accompanied by increases in diacylglycerol and translocative activation of the C-kinase system.

AB - Treatment of rats in vivo with ACTH provoked increases in whole adrenal contents of phosphatidylinositol and diacylglycerol. Concomitantly, C-kinase activity decreased in cytosol and increased stoichiometrically in the membrane fraction. It appears that the de novo phospholipid synthesis effect of ACTH is accompanied by increases in diacylglycerol and translocative activation of the C-kinase system.

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U2 - 10.1016/0024-3205(87)90277-3

DO - 10.1016/0024-3205(87)90277-3

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AN - SCOPUS:0023623513

SN - 0024-3205

VL - 41

SP - 2631

EP - 2637

JO - Life Sciences

JF - Life Sciences

IS - 24

ER -

ACTH increases diacylglycerol content and subcellular redistribution of protein kinase C in the rat adrenal in vivo

Abstract

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