Activation of human NK cells and monocytes with cisplatin in vitro

Ajit Sodhi, Kalpana Pai, Rakesh Kumar Singh, Sukh Mahendra Singh

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Human natural killer (NK) cells and monocytes treated in vitro concomitantly with cisplatin and rIFN-γ enhanced lysis of K562 cells. Lysis was dependent upon the duration of treatment. Cisplatin and rIFN-γ treated monocytes were equally cytotoxic to NK sensitive (K562) and NK resistant (Daudi & Raji) cell lines whereas NK cells were not rendered cytotoxic against NK resistant tumor cells. NK- and monocyte-mediated cytotoxicity against K562 cells was further enhanced when the effector cells were primed with rIFN-γ and were subsequently treated with cisplatin.

Original languageEnglish (US)
Pages (from-to)893-898
Number of pages6
JournalInternational Journal of Immunopharmacology
Volume12
Issue number8
DOIs
StatePublished - 1990

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

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