Activation of human NK cells and monocytes with cisplatin in vitro

Ajit Sodhi; Kalpana Pai; Rakesh Kumar Singh; Sukh Mahendra Singh

doi:10.1016/0192-0561(90)90008-B

Activation of human NK cells and monocytes with cisplatin in vitro

Ajit Sodhi, Kalpana Pai, Rakesh Kumar Singh, Sukh Mahendra Singh

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Human natural killer (NK) cells and monocytes treated in vitro concomitantly with cisplatin and rIFN-γ enhanced lysis of K562 cells. Lysis was dependent upon the duration of treatment. Cisplatin and rIFN-γ treated monocytes were equally cytotoxic to NK sensitive (K562) and NK resistant (Daudi & Raji) cell lines whereas NK cells were not rendered cytotoxic against NK resistant tumor cells. NK- and monocyte-mediated cytotoxicity against K562 cells was further enhanced when the effector cells were primed with rIFN-γ and were subsequently treated with cisplatin.

Original language	English (US)
Pages (from-to)	893-898
Number of pages	6
Journal	International Journal of Immunopharmacology
Volume	12
Issue number	8
DOIs	https://doi.org/10.1016/0192-0561(90)90008-B
State	Published - 1990
Externally published	Yes

ASJC Scopus subject areas

Immunology
Pharmacology

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title = "Activation of human NK cells and monocytes with cisplatin in vitro",

abstract = "Human natural killer (NK) cells and monocytes treated in vitro concomitantly with cisplatin and rIFN-γ enhanced lysis of K562 cells. Lysis was dependent upon the duration of treatment. Cisplatin and rIFN-γ treated monocytes were equally cytotoxic to NK sensitive (K562) and NK resistant (Daudi & Raji) cell lines whereas NK cells were not rendered cytotoxic against NK resistant tumor cells. NK- and monocyte-mediated cytotoxicity against K562 cells was further enhanced when the effector cells were primed with rIFN-γ and were subsequently treated with cisplatin.",

author = "Ajit Sodhi and Kalpana Pai and Singh, {Rakesh Kumar} and Singh, {Sukh Mahendra}",

note = "Funding Information: Acknowledgements -- This work has been supported with grants from the University Grants Commission and Indian Council of Medical Research, New Delhi. Some financial assistance from the School of Biotechnology, B.H.U. is also acknowledged. Dr Sukh Mahendra Singh is a Scientific Pool Officer of the Council for Scientific and Industrial Research, New Delhi.",

year = "1990",

doi = "10.1016/0192-0561(90)90008-B",

language = "English (US)",

volume = "12",

pages = "893--898",

journal = "International Journal of Immunopharmacology",

issn = "0192-0561",

publisher = "Elsevier B.V.",

number = "8",

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TY - JOUR

T1 - Activation of human NK cells and monocytes with cisplatin in vitro

AU - Sodhi, Ajit

AU - Pai, Kalpana

AU - Singh, Rakesh Kumar

AU - Singh, Sukh Mahendra

N1 - Funding Information: Acknowledgements -- This work has been supported with grants from the University Grants Commission and Indian Council of Medical Research, New Delhi. Some financial assistance from the School of Biotechnology, B.H.U. is also acknowledged. Dr Sukh Mahendra Singh is a Scientific Pool Officer of the Council for Scientific and Industrial Research, New Delhi.

PY - 1990

Y1 - 1990

N2 - Human natural killer (NK) cells and monocytes treated in vitro concomitantly with cisplatin and rIFN-γ enhanced lysis of K562 cells. Lysis was dependent upon the duration of treatment. Cisplatin and rIFN-γ treated monocytes were equally cytotoxic to NK sensitive (K562) and NK resistant (Daudi & Raji) cell lines whereas NK cells were not rendered cytotoxic against NK resistant tumor cells. NK- and monocyte-mediated cytotoxicity against K562 cells was further enhanced when the effector cells were primed with rIFN-γ and were subsequently treated with cisplatin.

AB - Human natural killer (NK) cells and monocytes treated in vitro concomitantly with cisplatin and rIFN-γ enhanced lysis of K562 cells. Lysis was dependent upon the duration of treatment. Cisplatin and rIFN-γ treated monocytes were equally cytotoxic to NK sensitive (K562) and NK resistant (Daudi & Raji) cell lines whereas NK cells were not rendered cytotoxic against NK resistant tumor cells. NK- and monocyte-mediated cytotoxicity against K562 cells was further enhanced when the effector cells were primed with rIFN-γ and were subsequently treated with cisplatin.

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Activation of human NK cells and monocytes with cisplatin in vitro

Abstract

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