Activation of murine macrophages by tumor necrosis factor, interleukin-1, interferon-γ and cisplatin

Ajit Sodhi; Rakesh Kumar Singh; Kalpana Pai

doi:10.1016/0165-2478(90)90174-O

Activation of murine macrophages by tumor necrosis factor, interleukin-1, interferon-γ and cisplatin

Ajit Sodhi, Rakesh Kumar Singh, Kalpana Pai

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Murine peritoneal macrophages were rendered tumoricidal to Dalton's lymphoma (DL) cells on incubation with recombinant tumor necrosis factor alpha (rTNF-α), recombinant interleukin-1 (rIL-1) and cisplatin in vitro. Simultaneous treatment of macrophages with suboptimal doses of rTNF-α and rIL-1 had additive effect on the activation of macrophages. Priming of macrophages with recombinant interferon gamma (rIFN-γ) significantly enhanced the rTNF-α and rIL-1-induced macrophage cytotoxicity. Cisplatin was found to up-regulate rIL-1-induced macrophage activation but inhibited the activation of macrophages with rTNF-α. These studies indicate the potential of appropriate combination of these Biological Response Modifiers (BRMs) against neoplasia.

Original language	English (US)
Pages (from-to)	45-50
Number of pages	6
Journal	Immunology Letters
Volume	26
Issue number	1
DOIs	https://doi.org/10.1016/0165-2478(90)90174-O
State	Published - Oct 1990
Externally published	Yes

Keywords

Cisplatin
Interferon-γ
Interleukin-1
Macrophage
Tumor necrosis factor

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/0165-2478(90)90174-O

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title = "Activation of murine macrophages by tumor necrosis factor, interleukin-1, interferon-γ and cisplatin",

abstract = "Murine peritoneal macrophages were rendered tumoricidal to Dalton's lymphoma (DL) cells on incubation with recombinant tumor necrosis factor alpha (rTNF-α), recombinant interleukin-1 (rIL-1) and cisplatin in vitro. Simultaneous treatment of macrophages with suboptimal doses of rTNF-α and rIL-1 had additive effect on the activation of macrophages. Priming of macrophages with recombinant interferon gamma (rIFN-γ) significantly enhanced the rTNF-α and rIL-1-induced macrophage cytotoxicity. Cisplatin was found to up-regulate rIL-1-induced macrophage activation but inhibited the activation of macrophages with rTNF-α. These studies indicate the potential of appropriate combination of these Biological Response Modifiers (BRMs) against neoplasia.",

keywords = "Cisplatin, Interferon-γ, Interleukin-1, Macrophage, Tumor necrosis factor",

author = "Ajit Sodhi and {Kumar Singh}, Rakesh and Kalpana Pai",

note = "Funding Information: This work was supported by grants from the University Grants Commission. Mr. Rakesh Kumar Singh is a CSIR Research Fellow. Ms. Kalpana Pai is a UGC Research Fellow.",

year = "1990",

month = oct,

doi = "10.1016/0165-2478(90)90174-O",

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pages = "45--50",

journal = "Immunology Letters",

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publisher = "Elsevier B.V.",

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TY - JOUR

T1 - Activation of murine macrophages by tumor necrosis factor, interleukin-1, interferon-γ and cisplatin

AU - Sodhi, Ajit

AU - Kumar Singh, Rakesh

AU - Pai, Kalpana

N1 - Funding Information: This work was supported by grants from the University Grants Commission. Mr. Rakesh Kumar Singh is a CSIR Research Fellow. Ms. Kalpana Pai is a UGC Research Fellow.

PY - 1990/10

Y1 - 1990/10

N2 - Murine peritoneal macrophages were rendered tumoricidal to Dalton's lymphoma (DL) cells on incubation with recombinant tumor necrosis factor alpha (rTNF-α), recombinant interleukin-1 (rIL-1) and cisplatin in vitro. Simultaneous treatment of macrophages with suboptimal doses of rTNF-α and rIL-1 had additive effect on the activation of macrophages. Priming of macrophages with recombinant interferon gamma (rIFN-γ) significantly enhanced the rTNF-α and rIL-1-induced macrophage cytotoxicity. Cisplatin was found to up-regulate rIL-1-induced macrophage activation but inhibited the activation of macrophages with rTNF-α. These studies indicate the potential of appropriate combination of these Biological Response Modifiers (BRMs) against neoplasia.

AB - Murine peritoneal macrophages were rendered tumoricidal to Dalton's lymphoma (DL) cells on incubation with recombinant tumor necrosis factor alpha (rTNF-α), recombinant interleukin-1 (rIL-1) and cisplatin in vitro. Simultaneous treatment of macrophages with suboptimal doses of rTNF-α and rIL-1 had additive effect on the activation of macrophages. Priming of macrophages with recombinant interferon gamma (rIFN-γ) significantly enhanced the rTNF-α and rIL-1-induced macrophage cytotoxicity. Cisplatin was found to up-regulate rIL-1-induced macrophage activation but inhibited the activation of macrophages with rTNF-α. These studies indicate the potential of appropriate combination of these Biological Response Modifiers (BRMs) against neoplasia.

KW - Cisplatin

KW - Interferon-γ

KW - Interleukin-1

KW - Macrophage

KW - Tumor necrosis factor

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JO - Immunology Letters

JF - Immunology Letters

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ER -

Activation of murine macrophages by tumor necrosis factor, interleukin-1, interferon-γ and cisplatin

Abstract

Keywords

ASJC Scopus subject areas

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