Activation of murine macrophages by tumor necrosis factor, interleukin-1, interferon-γ and cisplatin

Ajit Sodhi, Rakesh Kumar Singh, Kalpana Pai

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Murine peritoneal macrophages were rendered tumoricidal to Dalton's lymphoma (DL) cells on incubation with recombinant tumor necrosis factor alpha (rTNF-α), recombinant interleukin-1 (rIL-1) and cisplatin in vitro. Simultaneous treatment of macrophages with suboptimal doses of rTNF-α and rIL-1 had additive effect on the activation of macrophages. Priming of macrophages with recombinant interferon gamma (rIFN-γ) significantly enhanced the rTNF-α and rIL-1-induced macrophage cytotoxicity. Cisplatin was found to up-regulate rIL-1-induced macrophage activation but inhibited the activation of macrophages with rTNF-α. These studies indicate the potential of appropriate combination of these Biological Response Modifiers (BRMs) against neoplasia.

Original languageEnglish (US)
Pages (from-to)45-50
Number of pages6
JournalImmunology Letters
Volume26
Issue number1
DOIs
StatePublished - Oct 1990

Keywords

  • Cisplatin
  • Interferon-γ
  • Interleukin-1
  • Macrophage
  • Tumor necrosis factor

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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