Acute and Chronic Demyelinating Neuropathies after COVID-19 Vaccination: A Report of 4 Cases

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Abstract

Objectives:To report demyelinating neuropathies after COVID-19 vaccination.Methods:Case report.Results:Four cases of demyelinating neuropathies after COVID-19 vaccination were identified at the University of Nebraska Medical Center from May to September 2021. Three were male and 1 was a female, ages 26-64 years. Three cases received Pfizer-BioNTech vaccine and 1 Johnson & Johnson. Symptom onset ranged from 2 to 21 days after vaccination. Two cases had progressive limb weakness, 3 had facial diplegia, and all had sensory symptoms and areflexia. The diagnosis was acute inflammatory demyelinating polyneuropathy in 1 case and chronic inflammatory demyelinating polyradiculoneuropathy in 3. All cases received treatment with intravenous immunoglobulin, with significant improvement in 3 of 4 who had a long-Term outpatient follow-up.Conclusions:Continued identification and reporting of cases of demyelinating neuropathies after COVID-19 vaccination is essential to determine whether a causative association is present.

Original languageEnglish (US)
Pages (from-to)147-156
Number of pages10
JournalJournal of Clinical Neuromuscular Disease
Volume24
Issue number3
DOIs
StatePublished - Mar 1 2023

Keywords

  • COVID-19 vaccination
  • acute demyelinating polyneuropathy
  • chronic inflammatory demyelinating polyradiculoneuropathy
  • facial diplegia

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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