Acute Budd-Chiari syndrome during pregnancy: Surgical treatment and orthotopic liver transplantation with successful completion of the pregnancy

Wendy J. Grant, Timothy McCashland, Jean F. Botha, Byers W. Shaw, Debra L. Sudan, Alejandro Mejia, Kishore Iyer, Alan N. Langnas

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

A 26-year-old woman presented with acute Budd-Chiari syndrome 18 weeks into a pregnancy. She was found to be heterozygous for the G20210A prothrombin gene mutation. She was treated with portacaval shunt placement and successfully completed the pregnancy, with a healthy baby delivered at 31 weeks' gestation. She developed progressive liver failure after delivery of the child, likely associated with clotting of the shunt, which occurred in the face of full anticoagulation. The patient subsequently underwent a technically complicated orthotopic liver transplantation, but died 10 months after transplantation. This case illustrates the challenges involved in the treatment of Budd-Chiari syndrome, in addition to difficulties balancing the health of a mother and an unborn child. It is the only case of surgical treatment of Budd-Chiari syndrome during pregnancy reported in the literature.

Original languageEnglish (US)
Pages (from-to)976-979
Number of pages4
JournalLiver Transplantation
Volume9
Issue number9
DOIs
StatePublished - Sep 1 2003

ASJC Scopus subject areas

  • Surgery
  • Hepatology
  • Transplantation

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