Acute effect of nicotine on the striatal dopaminergic system in the rat

YIU K. FUNG, YUEN S. LAU

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

The acute effects of nicotine (1.5 mg kg−1 day−1) on the striatal dopaminergic system have been examined in the rat. Twenty‐four hours after nicotine treatment, spontaneous locomotor activity in response to apomorphine or (+)‐amphetamine and the binding of [3H]spiperone to striatal particulates were determined. Pretreatment of nicotine did not alter the characteristics of [3H]spiperone binding to striatal dopamine receptors. The nicotine treatment did not affect the apomorphine‐induced locomotor activity, however, the (+)‐ampnetamine‐stimulated locomotor activity was attenuated. These results suggest that nicotine acutely alters the presynaptic dopaminergic activity without significantly affecting the postsynaptic dopaminergic function. 1986 Royal Pharmaceutical Society of Great Britain

Original languageEnglish (US)
Pages (from-to)920-922
Number of pages3
JournalJournal of Pharmacy and Pharmacology
Volume38
Issue number12
DOIs
StatePublished - Dec 1986

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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