Acute epigastric and low back pain during amiodarone infusion; is it the drug or the vehicle to blameα

Emmanouil Petrou, Ioannis Iakovou, Maria Boutsikou, Chrysafios Girasis, Sophie Mavrogeni, Gregory Pavlides

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Amiodarone is a Class III antiarrhythmic agent used for cardioversion and prevention of recurrences of atrial fibrillation. However, its use is limited due to its side-effects resulting from the drug's long-term administration. We have described acute epigastric pain following treatment with intravenous amiodarone for atrial fibrillation in a previous report. Hereby, we describe a second patient who suffered acute epigastric pain, as well as one who suffered acute low back pain. Intravenous amiodarone has been related to a series of minor and major adverse reactions, indicating other constituents of the intravenous solution as the possible cause, possibly polysorbate-80. A possible correlation between acute epigastric and low back pain after intravenous amiodarone loading is unproven; however it is of crucial importance for clinicians to be aware of this phenomenon, and especially since an acute epigastric pain is implicated in the differential diagnosis of cardiac ischemia.

Original languageEnglish (US)
Pages (from-to)60-61
Number of pages2
JournalHeart and Lung: Journal of Acute and Critical Care
Issue number1
StatePublished - Jan 2014
Externally publishedYes


  • Epigastric pain
  • Intravenous amiodarone
  • Low back pain

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Acute epigastric and low back pain during amiodarone infusion; is it the drug or the vehicle to blameα'. Together they form a unique fingerprint.

Cite this