Acute graft-versus-host disease resulting from normal donor blood transfusions1

Linda J. Burns, Mark W. Westberg, C. Patrick Burns, Lynell W. Klassen, Nancy E. Goeken, Thomas L. Ray, Donald E. Macfarlane

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


2 fatal cases of graft-versus-host disease (GvHD) occurred following blood product transfusions given to patients receiving standard chemotherapy for Hodgkin's disease. GvHD was established by HLA typing, clinical course, and compatible skin biopsy. 23 cases of GvHD following transfusion of blood products from normal donors are also reviewed. It should be suspected when fever or rash appear 1-2 weeks after transfusion of unirradiated blood products into a compromised host or when pancyto-penia following chemotherapy is prolonged or unexpectedly severe. Prevention of GvHD by irradiation of granulocytes, platelets and packed red blood cells given to im-munosuppressed patients is recommended to prevent this often fatal disease.

Original languageEnglish (US)
Pages (from-to)270-276
Number of pages7
JournalActa Haematologica
Issue number4
StatePublished - 1984
Externally publishedYes


  • Graft-versus-host disease
  • Transfusions

ASJC Scopus subject areas

  • Hematology


Dive into the research topics of 'Acute graft-versus-host disease resulting from normal donor blood transfusions1'. Together they form a unique fingerprint.

Cite this