Acute lymphoblastic leukemia of NK-cell lineage: Responses to IL-2

Samuel J. Pirruccello; Molly S. Bicak; Bruce G. Gordon; Kazimiera Gajl-Peczalska; David J. Gnarra; Peter F. Coccia

doi:10.1016/0145-2126(89)90086-6

Acute lymphoblastic leukemia of NK-cell lineage: Responses to IL-2

Samuel J. Pirruccello, Molly S. Bicak, Bruce G. Gordon, Kazimiera Gajl-Peczalska, David J. Gnarra, Peter F. Coccia

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Acute lymphoblastic leukemias with phenotypic characteristics of natural killer cell derived lineage are extremely uncommon. We identified an ALL with a phenotype consistent with an NK-cell of origin. The blasts underwent a proliferative response to r-IL2 in culture but showed no spontaneous or r-IL2 or γ-INF induced cytotoxicity. With r-IL2 stimulation however, the tumor cells demonstrated a dramatic acquisition of low density CD8 surface positivity and a loss of CD11b expression after short term culture. By comparison to ALL of B or T lineage, NK ALL likely represents an early stage of bone marrow derived NK-cell precursor.

Original language	English (US)
Pages (from-to)	735-743
Number of pages	9
Journal	Leukemia Research
Volume	13
Issue number	9
DOIs	https://doi.org/10.1016/0145-2126(89)90086-6
State	Published - 1989

Keywords

Acute lymphoblastic leukemia
CD11b
CD8
interleukin 2
natural killer cell
phenotype

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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10.1016/0145-2126(89)90086-6

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title = "Acute lymphoblastic leukemia of NK-cell lineage: Responses to IL-2",

abstract = "Acute lymphoblastic leukemias with phenotypic characteristics of natural killer cell derived lineage are extremely uncommon. We identified an ALL with a phenotype consistent with an NK-cell of origin. The blasts underwent a proliferative response to r-IL2 in culture but showed no spontaneous or r-IL2 or γ-INF induced cytotoxicity. With r-IL2 stimulation however, the tumor cells demonstrated a dramatic acquisition of low density CD8 surface positivity and a loss of CD11b expression after short term culture. By comparison to ALL of B or T lineage, NK ALL likely represents an early stage of bone marrow derived NK-cell precursor.",

keywords = "Acute lymphoblastic leukemia, CD11b, CD8, interleukin 2, natural killer cell, phenotype",

author = "Pirruccello, {Samuel J.} and Bicak, {Molly S.} and Gordon, {Bruce G.} and Kazimiera Gajl-Peczalska and Gnarra, {David J.} and Coccia, {Peter F.}",

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T1 - Acute lymphoblastic leukemia of NK-cell lineage

T2 - Responses to IL-2

AU - Pirruccello, Samuel J.

AU - Bicak, Molly S.

AU - Gordon, Bruce G.

AU - Gajl-Peczalska, Kazimiera

AU - Gnarra, David J.

AU - Coccia, Peter F.

PY - 1989

Y1 - 1989

N2 - Acute lymphoblastic leukemias with phenotypic characteristics of natural killer cell derived lineage are extremely uncommon. We identified an ALL with a phenotype consistent with an NK-cell of origin. The blasts underwent a proliferative response to r-IL2 in culture but showed no spontaneous or r-IL2 or γ-INF induced cytotoxicity. With r-IL2 stimulation however, the tumor cells demonstrated a dramatic acquisition of low density CD8 surface positivity and a loss of CD11b expression after short term culture. By comparison to ALL of B or T lineage, NK ALL likely represents an early stage of bone marrow derived NK-cell precursor.

AB - Acute lymphoblastic leukemias with phenotypic characteristics of natural killer cell derived lineage are extremely uncommon. We identified an ALL with a phenotype consistent with an NK-cell of origin. The blasts underwent a proliferative response to r-IL2 in culture but showed no spontaneous or r-IL2 or γ-INF induced cytotoxicity. With r-IL2 stimulation however, the tumor cells demonstrated a dramatic acquisition of low density CD8 surface positivity and a loss of CD11b expression after short term culture. By comparison to ALL of B or T lineage, NK ALL likely represents an early stage of bone marrow derived NK-cell precursor.

KW - Acute lymphoblastic leukemia

KW - CD11b

KW - CD8

KW - interleukin 2

KW - natural killer cell

KW - phenotype

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Acute lymphoblastic leukemia of NK-cell lineage: Responses to IL-2

Abstract

Keywords

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