Abstract
Transient myeloproliferative disorder (TMD) and subsequent acute myeloid leukemia (AML) occur with increased frequency in infants and children with Down syndrome. TMD can also occur in phenotypically normal newborns. We describe the second case of a non‐Down syndrome child with TMD who subsequently developed AML. Trisomy 21 karyotype was restricted to hematopoietic cells in the blood and bone marrow. No other karyotypic abnormalities were found. Leukemic blasts showed megakaryoblastic features with immunophenotyping. This case shows that TMD in a child without Down syndrome may not be entirely benign. Close follow‐up is warranted. © 1994 Wiley‐Liss, Inc.
Original language | English (US) |
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Pages (from-to) | 316-319 |
Number of pages | 4 |
Journal | American Journal of Hematology |
Volume | 47 |
Issue number | 4 |
DOIs | |
State | Published - Dec 1994 |
Keywords
- acute leukemia
- transient myeloproliferative disorder
- trisomy 21
ASJC Scopus subject areas
- Hematology