Acute megakaryoblastic leukemia following transient myeloproliferative disorder in a patient without down syndrome

Mark D. Brissette, Bertrand J. Duval‐Arnould, Bruce G. Gordon, James D. Cotelingam

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Transient myeloproliferative disorder (TMD) and subsequent acute myeloid leukemia (AML) occur with increased frequency in infants and children with Down syndrome. TMD can also occur in phenotypically normal newborns. We describe the second case of a non‐Down syndrome child with TMD who subsequently developed AML. Trisomy 21 karyotype was restricted to hematopoietic cells in the blood and bone marrow. No other karyotypic abnormalities were found. Leukemic blasts showed megakaryoblastic features with immunophenotyping. This case shows that TMD in a child without Down syndrome may not be entirely benign. Close follow‐up is warranted. © 1994 Wiley‐Liss, Inc.

Original languageEnglish (US)
Pages (from-to)316-319
Number of pages4
JournalAmerican Journal of Hematology
Volume47
Issue number4
DOIs
StatePublished - Dec 1994

Keywords

  • acute leukemia
  • transient myeloproliferative disorder
  • trisomy 21

ASJC Scopus subject areas

  • Hematology

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