Acute megakaryoblastic leukemia following transient myeloproliferative disorder in a patient without down syndrome

Mark D. Brissette; Bertrand J. Duval‐Arnould; Bruce G. Gordon; James D. Cotelingam

doi:10.1002/ajh.2830470413

Acute megakaryoblastic leukemia following transient myeloproliferative disorder in a patient without down syndrome

Mark D. Brissette, Bertrand J. Duval‐Arnould, Bruce G. Gordon, James D. Cotelingam

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Transient myeloproliferative disorder (TMD) and subsequent acute myeloid leukemia (AML) occur with increased frequency in infants and children with Down syndrome. TMD can also occur in phenotypically normal newborns. We describe the second case of a non‐Down syndrome child with TMD who subsequently developed AML. Trisomy 21 karyotype was restricted to hematopoietic cells in the blood and bone marrow. No other karyotypic abnormalities were found. Leukemic blasts showed megakaryoblastic features with immunophenotyping. This case shows that TMD in a child without Down syndrome may not be entirely benign. Close follow‐up is warranted. © 1994 Wiley‐Liss, Inc.

Original language	English (US)
Pages (from-to)	316-319
Number of pages	4
Journal	American Journal of Hematology
Volume	47
Issue number	4
DOIs	https://doi.org/10.1002/ajh.2830470413
State	Published - Dec 1994

Keywords

acute leukemia
transient myeloproliferative disorder
trisomy 21

ASJC Scopus subject areas

Hematology

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10.1002/ajh.2830470413

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AB - Transient myeloproliferative disorder (TMD) and subsequent acute myeloid leukemia (AML) occur with increased frequency in infants and children with Down syndrome. TMD can also occur in phenotypically normal newborns. We describe the second case of a non‐Down syndrome child with TMD who subsequently developed AML. Trisomy 21 karyotype was restricted to hematopoietic cells in the blood and bone marrow. No other karyotypic abnormalities were found. Leukemic blasts showed megakaryoblastic features with immunophenotyping. This case shows that TMD in a child without Down syndrome may not be entirely benign. Close follow‐up is warranted. © 1994 Wiley‐Liss, Inc.

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Acute megakaryoblastic leukemia following transient myeloproliferative disorder in a patient without down syndrome

Abstract

Keywords

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