Acute myelogenous leukemia with eosinophilic differentiation and trisomy-1

D. S. Harrington, C. Peterson, M. Ness, W. Sanger, D. M. Smith, W. Vaughan

Research output: Contribution to journalReview article

14 Scopus citations

Abstract

A 50-year-old woman presented with anemia and eosinophilia. Her bone marrow biopsy, peripheral blood, and clinical features were consistent with a diagnosis of an evolving acute myelogenous leukemia. Striking dysplastic eosinophilic differentiation associated with trisomy-1 was evident, and eosinophil granule major basic protein was detected in involved tissue. Trisomy-1 has not been previously reported in association with acute myelogenous leukemia showing eosinophilic differentiation. Intensive cytotoxic chemotherapy produced a short-lived clinical and cytogenetic remission. At autopsy multiple tumor nodules composed of dysplastic eosinophil precursors and myeloblasts were evident in multiple organs.

Original languageEnglish (US)
Pages (from-to)464-469
Number of pages6
JournalAmerican journal of clinical pathology
Volume90
Issue number4
DOIs
StatePublished - 1988

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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