Acute phase proteins in serum and milk from dairy cows with clinical mastitis

P. D. Eckersall, F. J. Young, C. McComb, C. J. Hogarth, S. Safi, A. Weber, T. McDonald, A. M. Nolan, J. L. Fitzpatrick

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239 Scopus citations

Abstract

The serum concentrations of haptoglobin, serum amyloid A and α1 acid glycoprotein were determined in serum collected from healthy dairy cows and cows with clinical mastitis, graded as mild (clots in milk) or moderate (clots in milk and visible signs of inflammation in the mammary gland/s) to assess their relative diagnostic value in detecting the disease. The concentrations of haptoglobin and serum amyloid A were also measured in milk collected from infected and uninfected quarters. The concentrations of haptoglobin and serum amyloid A were higher in the serum and milk from the cows with mild or moderate mastitis. The diagnostic value of haptoglobin in differentiating between healthy animals and those with mastitis gave sensitivities and specificities of 82 per cent and 94 per cent respectively with serum and 86 per cent and 100 per cent with milk. The diagnostic value of serum amyloid A in differentiating between healthy animals and those with mastitis gave sensitivities and specificities of 83 per cent and 90 per cent with serum and 93 per cent and 100 per cent with milk. The diagnostic value of serum α1 acid glycoprotein in differentiating between healthy animals and those with mastitis gave sensitivities and specificities of 62 per cent and 91 percent.

Original languageEnglish (US)
Pages (from-to)35-41
Number of pages7
JournalVeterinary Record
Volume148
Issue number2
DOIs
StatePublished - Jan 13 2001

ASJC Scopus subject areas

  • veterinary(all)

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    Eckersall, P. D., Young, F. J., McComb, C., Hogarth, C. J., Safi, S., Weber, A., McDonald, T., Nolan, A. M., & Fitzpatrick, J. L. (2001). Acute phase proteins in serum and milk from dairy cows with clinical mastitis. Veterinary Record, 148(2), 35-41. https://doi.org/10.1136/vr.148.2.35